Black pepper / Piperene / Bioperine and metformin and blood glucose

Well how about this, I've been picking up information for about nine years now on dietary practices and blood glucose, but this may be the biggest of all and I've managed to be unaware of it, not seen it mentioned, and of course never heard it from a doctor or other health worker.

I've known that black pepper, and the active ingredient piperene, is often mixed with other supplements to help with their absorption. I thought it was only through blocking some of the cytochrome enzymes that clear and destroy active ingredients, and it does do that, but it also has direct beneficial effects on glucose metabolism!

One immediate fact is it slows the clearing of metformin and should certainly be taken with great care for anyone on metformin. I didn't realize until recently that my magnesium glycinate capsules also contain a small amount of this Bioperine. Yikes!

Since the chatbot was chatty I also mentioned taking curcumin and celery seed supplements, and it told me immediately those too would be facilitated (or worse) by piperene. These supplements do not contain any piperine.

Does anyone out there have any more knowledge about this?

I had this chat with just plain old GoogleAI, which seems to have been upgraded recently to just about full Google Gemini capacity. I can post my discussion here if anyone likes.

I got into this because I recently cheated (!) with some potato chips flavored with sea salt and black pepper. A modest serving, to my amazement, had little, or no, or beneficial effects on my blood glucose! And I repeated this (harrumph!) a couple of times to validate. Other flavors of chips (harrumph!) were not so beneficial, of course. Nor, as the chatbot reminds me, is this a license to eat more potato chips. But it sure does seem a good topic to know about.