Is Hormone therapy necessary With radiation

Posted by Jeff Marchi @jeffmarc, 5 days ago

A few different people have asked about this in the last few days so here is some information about it.

Advantage of radiation and hormone therapy given at the same time greatly reduced
Overall survival—the chance of being alive years later—was nearly the same whether or not men received hormones with their radiation. After 10 years of follow‑up, 83.6% of men treated with radiation alone were alive, compared with 84.3% of men who also had hormone therapy, a difference of only 0.7%. Statistically, that small gap did not reach the usual bar for significance, meaning it may simply be due to chance.
However, the story changed when researchers looked at PSA level before radiation. Men whose PSA was 0.5 ng/mL or lower when they started radiation did not live longer if they added hormone therapy—whether they took it for a few months or for two full years. Men whose PSA was higher than 0.5 ng/mL, on the other hand, did see some survival benefit from adding hormones, suggesting that hormone therapy makes the most sense for this higher‑risk group.
The study also examined how long hormone therapy should last. Short‑term therapy (about 4–6 months) performed just as well as long‑term therapy (about 24 months) for most men in terms of overall survival. Longer treatment appeared to reduce the chance of the cancer spreading, but it did not clearly translate into men living longer overall in the general study population. Based on these data. Kishan summarized: for men who truly need it, a short course of hormone therapy is usually enough.
https://prostateblogmonthly.substack.com/p/do-all-men-need-hormone-therapy-after
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00137-6/fulltext

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Profile picture for im62at2024 @im62at2024

@jeffmarc
My most recent post-op Gleason scores from early 2025 are two comments above yours. Here was my Gleason scores from 2021. I hope this helps because I don't have access to much more info than this.

1. Prostate, "Les 1 Rt posterior lateral peripheral zone", needle core biopsy:
-Prostatic adenocarcinoma, Gleason score 3+3 = 6, grade group 1, involving 10% of 1 core
2. Prostate, right base, needle core biopsy:
-Prostatic adenocarcinoma, Gleason score 3+3 = 6, grade group 1, involving 5% of 1 core
3. Prostate, right mid, needle core biopsy:
-Benign prostate tissue with atrophy
4. Prostate, right apex, needle core biopsy:
-Benign prostate tissue with atrophy
5. Prostate, left base, needle core biopsy:
-Benign prostate tissue
6. Prostate, left mid, needle core biopsy:
-Benign prostate tissue with focal acute inflammation
7. Prostate, left apex, needle core biopsy:
-Benign prostate tissue

Clinical Information
Diagnosis:
R97.20 - Elevated PSA [ICD-10-CM]

Here is my "Oncotype DX Genomic Prostate Score*" from 2021. As far as I'm concerned it couldn't have been more wrong. Also attached is all my PSA history.

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@im62at2024
Looking at your 2025 biopsy what your doctor has recommended makes sense to me. I started off with surgery and had no ADT for 3 1/2 years after. I was a 4+3. Then my PSA started rising so they gave me a 6 Month Lupron shot And two months later, I had salvage radiation. No more ADT until my PSA started rising again.

I didn’t find out until many years later that I had BRCA2 and that is why it keeps coming back. If I didn’t have it, the first surgery might have ended the whole thing. That’s where you’re at today. A 4+3 With the possibility that you won’t have a reoccurrence. If you want to get monthly blood tests and see if The PSA start starts coming back up. It may not.

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