so is it ok to take Orgovyx and Nubeqa at same time ?

Well...you're still on the right side of the grass so it can't be that bad. 🤣🤣🤣

I don't remember being told to take them separately, just that Nubeqa should be taken with food. Although I do take Nubeqa at 6 & 6 and Orgovyx at noon so maybe they did tell me to take them separately.

Well, that's what my oncologist just prescribed, so it must be OK. I've been on it a couple months.

Actually, that's standard of care for metastatic or high-risk prostate cancer these days: take ADT (like Orgovyx or Lupron) and an ARSI (like Nubeqa or Zytiga) together, right from the start. It's often called "doublet therapy."

If the patient has high-load metastatic cancer, toss in chemotherapy, then you have "triplet therapy."

These new ways of using existing treatments all together up front (rather than the old incrementalist approach) have improved our prospects drastically. Additional options for low-load oligometastatic prostate cancer include metastasis-directed therapy (MDT) and prostate-directed radiotherapy (PDRT); for high-load polymetastatic prostate cancer, there are also radioligands like Pluvicto.

The idea these days is to shock and awe metastatic or high-risk prostate cancer at the beginning, rather than attacking it in dribs and drabs, escalating to the next treatment only when the previous one fails.

@northoftheborder yes..I had Gleason 8 ( very small amt in prostate) + Gleason 7. 4 cores altogether and 8 benign+ 2 iliac nodes with small uptake. Rx Orgovyx+ erleada early but couldnt tolerate. So I stopped taking everything for a few weeks. Then started back with orgovyx and a few weeks later, oncologist added nubeqa. PSA went down to .05 in fist 6 weeks ( even while I stopped) then after I started IMRT, PSA dropped <.02- then at CHristmas it was <.01 and stayed there so far. Next PSA is in 2 weeks or so.

SO I assume I am doing something right on ADT doseage...( the erleada and orgovyx early on nearly killed me tho-could not tolerate)

I take Nubeqa at 7 in the morning and at seven at night along with the Orgovyx.

I take the Orgovyx At night because I take Prilosec in the morning and it conflicts with Orgovyx And can cause more side effects like hot flashes. Hot flashes went way down when I switched from taking the Orgovyx in the morning.

@jeffmarc Interesting. I also take my -lutamide (Erleada in my case) in the morning and Orgovyx before bed. I can't remember why — maybe the doctor or pharmacist recommended it when I switched from monthly Firmagon injections a couple of years ago (?)

@xahnegrey40 wrote "the erleada and orgovyx early on nearly killed me tho-could not tolerate"

I'm sorry to hear that. It's interesting how we all handle meds differently. I've been on that combo for nearly 5 years with nothing but the normal, manageable low-testosterone side-effects from the ADT.

On the other hand, a few weeks of a steroid in hospital in 2021 did a real number on me, as did a couple of days of opiod-based pain killers after 10+ hours of spinal surgery.

Most people tolerate those fine, but they made my life miserable (and gave me temporary steroid-induced diabetes, requiring insulin shots), so we had to stop both. I preferred the post-op pain over the opiod side-effects.

I take both also. Was taking Orgovyx in the morning with my 1st dose of Nubeqa. Side effects were pretty bad. So l switched to taking the Orgovyx at bedtime. Not so bad now.