Not Good News after prostate biospy when MRI didn't look too bad
Last month I had PSA of 5.23 when a few months earlier it was 3.2. Then they scheduled me for MRI of prostate. Did another PSA and it was down to 4.16, but still wanted the MRI. Report is below, doesn't look good PI-RADS 5. At one point they say in report Lesions (PI-RADS 3 or higher). If I understand it, it hasn't spread. Wish I could get a plan with doctor!
FINDINGS:
Prostate measurement: 5.7 x 5.0 x 4.9 cm Prostate volume: 68.75 cc PSA: 4.16 ng/mL PSA density: 0.06 ng/mL/cc
Peripheral zone: See below.
Transition zone: No index lesion. Stromal and glandular BPH nodules.
Lesions (PI-RADS 3 or higher):
Lesion # 1: Location: Left posterior peripheral zone extending from the base to the apex Size: 2.4 x 1.3 x 2.6 cm (5.83 cc). T2: T2
hypointense DWI: Marked restricted diffusion DCE: Focal early enhancement, positive Prostate margin: Abuts the capsule without
definite invasion Overall PI-RADS Score: 5/5
Prostatic capsule: Intact.
Neurovascular bundles: Not involved.
Seminal vesicles: Not involved.
Lymph nodes: No lymphadenopathy.
Bones: No acute osseous abnormality.
Other findings: Small fat-containing right inguinal hernia.
IMPRESSION:
1. The prostate gland measures 5.7 x 5.0 x 4.9 cm with volume of 68.75 cc. PSA density is 0.06 NG/mL/CC. 2. Lesion # 1: PI-
RADS 5 lesion in the left posterior peripheral zone extending from the base to the apex measures 5.83 cc. No frank extracapsular
extension. 3. No pelvic lymphadenopathy.
PI-RADS Category 5: Very high (clinically significant prostate cancer is highly likely to be present)
Really doesn't look to bad, one spot that hasn't spread!
Then Bad Update 2/10/2026
Well got biopsy yesterday and results today, doctor hasn't called, just sent biopsy results to MyChart.
The MRI showed only one Lesion like shown above. Had biopsy done yesterday, they did 3 from the Lesion and 6 from each side of prostate. I wondered why they did more biopsy that were outside the lesion, but didn't ask. Got report today- not good. The lesion look better than areas where MRI saw nothing. They took 15 samples total.
Results:
Final Diagnosis
View trends
A. Prostate, "LLB", biopsy:
Prostatic adenocarcinoma Gleason score 3+4=7 (Grade group 2) in 1 of 1 core, involving 30% of needle core tissue.
B. Prostate, "LMB", biopsy:
Prostatic adenocarcinoma Gleason score 4+3=7 (Grade group 3) in 1 of 1 core, involving 70% of needle core tissue
C. Prostate, "LLM", biopsy:
Prostatic adenocarcinoma Gleason score 3+4=7 (Grade group 2) in 1 of 1 core, involving 60% of needle core tissue.
D. Prostate, "LMM", biopsy:
Prostatic adenocarcinoma Gleason score 4+3=7 (Grade group 3) in 1 of 1 core, involving 60% of needle core tissue.
Large cribriform glands present.
E. Prostate, "LLA", biopsy:
Prostatic adenocarcinoma Gleason score 3+4=7 (Grade group 2) in 1 of 1 core, involving 60% of needle core tissue.
F. Prostate, "LMA", biopsy:
Prostatic adenocarcinoma Gleason score 3+4=7 (Grade group 2) in 1 of 1 core, involving 50% of needle core tissue.
G. Prostate, "RLB", biopsy:
Benign prostatic tissue.
H. Prostate, "RMB", biopsy:
Prostatic adenocarcinoma Gleason score 4+3=7 (Grade group 3) in 1 of 1 core, involving 10% of needle core tissue.
I. Prostate, "RLM", biopsy:
Benign prostatic tissue.
J. Prostate, "RMM", biopsy:
Prostatic adenocarcinoma Gleason score 4+3=7 (Grade group 3) in 1 of 1 core, involving 50% of needle core tissue
Large cribriform glands present.
K. Prostate, "RLA", biopsy:
Benign prostatic tissue.
L. Prostate, "RMA", biopsy:
Prostatic adenocarcinoma Gleason score 4+3=7 (Grade group 3) in 1 of 1 core, involving 25% of needle core tissue
M. Prostate, "ROI#1", biopsy:
Prostatic adenocarcinoma Gleason score 3+4=7 (Grade group 2) in 3 of 3 cores involving 70% of needle core tissue
Another thread I posted in a person said "You have a Gleason 4+3 7 BUT you have large cribriform and doctors a UCSF say that puts a 5 in your Gleason score." I believe he picked this up from the biopsy report. I don't know what a cribriform even is, it's not mention in report. From googling around it can only be determined by sieve-like or "Swiss cheese" appearance under a microscope and I don't see that in report? But this is all new to me. Doctors haven't talked to me yet, who knows when they will call or make appointment, took long time to get MRI and even longer to get the biopsy done. Sure were fast getting results, they said 7 - 10 days and they gave them to me the next day. Kind of wish they didn't give me results prior to talking with me.
My first thought is just get the thing cut out, not sure how that is done, as seems they got to leave something in there for urine to flow threw. So they couldn't take 100 percent of prostate out. Then I read about nerve sparing or not and not sure what that means. No doctors have discussed this with me yet. Seems if they take it out there shouldn't be any prostate cancer left? But then I read where people get it out and still have a PSA level, so like I said earlier, they must leave some in there, even when they call it total. Had to drive 150 miles to get MRI and biopsy They could have done that in Topeka, but KUMC is ranked as number 50 in top of prostate treatment so I went there Topeka doesn't have a Proton device, that would be back up to KUMC 150 miles RT. One of those radiations therapy is only a few days, not 30 some days. They do have SBRT radiation in Topeka, but I know of someone who had SBRT or maybe it was IMRT and it screwed up several other organs around the prostate, like bladder, kidneys and intestines.
Then some tell me I am lucky to have them all in grade group 2 or 3. But seems like I had a lot of them (12 of the 15) . So I would guess if they did 25 biopsy I could have had more grade group 2 or 3.
All confusing and stressful, other that this I am 78 years old healthy as a horse- no other issues and very active. Loss of what to do and all the different radiation types, that why just getting the pesky thing cut out of there, but seems they still leave some in.
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@diverjer - not sure what the objection to the implanted loop recorder is, but if it helps, my wife had one, and it was an older model, so about the size of a nickel, implanted sort of above her left breast. Implanted and removed with outpatient procedures. Today’s are about the size of a grain of rice, and I think they break down and are absorbed by the body over time.
Nifty in that she had an app on her phone, and that transmitted data to the manufacturer’s clinic in Tennessee (I think) 24/7, and then she went into her cardiologist’s office once a month (or maybe once a quarter) to have additional data read/downloaded there.
I just had a halter monitor for 30 days, and while it certainly didn’t slow me down, it was a much bigger PITA than her loop recorder. I had to keep my chest shaved, change out sticky patches every few days, carry a second phone with me everywhere, and put up with constant false alarms that it wasn’t working or was out of range or whatever. I’d roll over on one side at night…BEEP! BEEP! BEEEEEEEPPPPP!!!!! - it was an annoyance daily.
I will say this about the loop recorder - both my wife’s PCP and her cardiologist grinned when she ended up getting one. Both acknowledged that heart doctors love those things because they generate a significant amount of easy income!
Good luck, either which way you go.
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1 Reaction@diverjer Please do the loop recorder! It is tiny and not bothersome, placed under the skin. You need that data transmitted and monitored constantly. Please reconsider your refusal--don't take a huge unnecessary risk.
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2 Reactions@diverjer
Have they put you on a blood thinner? They put me on one shortly after I had an afib event from Zytiga. That can prevent a stroke, which an afib can cause. I had a continuous afib for three days, that they put me in the hospital for. The fact that I was on a blood thinner allowed me to avoid a stroke.
If they think you had a TIA then it sure would seem to make sense To avoid another one.
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2 Reactions@jeffmarc
They put me on Plavix 75mg for 21 days and a baby aspirin forever.
This prostate surgery seems too have taken someone in good shape for 79 and did more harm than good.
Still feel weak and light headed, but I still get out and walk, did 3 miles yesterday. Doesn't bother me at all, doc said I could start lifting weights again, but limit to 40 pounds. That seems a waste, they will laugh at me at the gym. Haven't went back to any weights yet because I know there will be lots of stress incontinence. Darn peeing issues drives me nuts. Never feel like need to pee during day unless I sit or lie on couch and read book for an hour, then pee just a little bit. Mostly just drip and stress incontinence at the slightest movement all day long. Strangely not much leakage after I get walking, but no feeling of needing to go after walk.
Now at night while sleeping I have the urge to pee really bad, 4 - 6 times and shoot a stream out like a teenager! But still leak all night and sometimes have to change the overnight Depends around 4 or 5 am. Why I have an urge at night and not during the day is a mystery. Drink lots of water during day. I stop drinking liquid around 7 or 8 PM and go to bed around 11PM to 11:30PM.
Okay guys, I am listening and will stop being stubborn. Sent a message to heart doctor I would do the TEE Loop Recorder if it's not too late.
I am just so tired of tests and those surgeries so close together and blood loss as well as suspected TIA just has me in the dumpster.
Then I won't get into the stress of gut building home next to us, dug basement hole and now with lots of heavy rains, has washed out my yard almost to house. Much of my yard is sitting in his basement hole along with my sprinkler heads and gutter popups.
I am not handling all this well.
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2 Reactions@diverjer
Don’t worry about using lower weights. What you want to do is enough reps that you can’t do anymore, that’s the key to getting a buildup of muscle. Your doctor having you do the lighter weights just because you are recovering. Once you are fully recovered from the surgery, you can move back up in weight.
Hopefully the incontinence will get better over time. It usually does.
Though I will leak really Heavily if I’m moving around a lot, I don’t leak it all laying down unless I sneeze or cough.
Yours should get a lot better, He does for most surgery patients.
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2 Reactions@jeffmarc
Hope so, I just put the cover on my pickup bed and soak one pad.
Was kind of wondering why oncologist said PSA should be undetectable (less than 0.1 ng/mL). Would then watch my PSA every 3 months. If it does not decrease to undetectable or it recurs (past 0.1 ng/mL per NCCN, 0.2 per AUA), would consider salvage radiation given his multiple high risk features.
I thought they would be looking for numbers like .XX, not .X. I have a PSA test scheduled for 6/10 and 8/20. Asked doctor's office if I understood right, their first test is not a uPSA test, just a normal PSA. Reply from nurse:
Our standard of care is a regular PSA blood test and it will show if it is undetectable at less than 0.1 ng/mL, If you have further questions or concerns, please discuss with Dr. during your follow up appointment 8/24/26.
Seems also the NCCN and AUA have a big difference in their numbers.
@lag
Get the loop monitor installed Friday. Said I could use app on phone or have bedside thing that automatically uploaded data daily. I said I would use the bedside monitor. She thought that would be easier. I guess I could switch to app if I wanted? Don't know what you do if traveling, will ask. Said they would call if something showed up bad, otherwise I would never ever hear from them. I kind of wonder if a person even looks at the data or where it's sent. I would bet not local office? Just some computer program in some big corporations office. I will ask, said I could drive myself home. Some weight lifting and bathing restrictions for week or so.
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4 Reactions@diverjer You are wise to get the loop monitor put in. I do think that the data is monitored, likely by the doctor's office who ordered the monitor for you. When you get the monitor installed on Friday, you can ask about who sees the data and how often and who will contact you if they have concerns. Since it just stays in place under the skin, travel shouldn't present any additional issues, as it should be able to transmit from anywhere you are. But that is a good question to ask on Friday too. Your friends on this forum are relieved about your decision, and will be interested in how your appointment goes. Please do keep us posted, and good luck. We are sending positive thoughts. 😊
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3 Reactions