@jodyjazz My hematologist and I had the same problem with the Hydroxyurea: how much is enough and how much is too much? It took months to work it out by trial and error. We did work out a dosage that is 1 dose per day for two consecutive days, followed by 2 doses for one day, then back to 1, etc. It's cyclical. But, there were times when that didn't always work, especially if I was eating food that raises platelets, such as dairy, green leafy vegetables and fatty fish (salmon and tuna). You know, the foods doctors and nutritionists advise everyone to eat for their Omega 3 fatty acids, etc. One diet doesn't fit all. But, as I have pointed out here, several times, the reason I want to stop using Hydroxyurea, if I can, is because it causes my red blood cells to be too low. Then there is the side effect everyone here is talking about: oversensitivity to sunlight. If I can achieve the goal of keeping my platelet count normal without drugs, then my red cell count will be normal, my face won't be red, and that's the way it should be. If it doesn't work, then I'll continue the Hydroxyurea with all the problems it causes.