Pluvicto - How long do side effects last?

The results are all over the place. I know one guy who would go 10 days where we could barely eat was absolutely fatigued and then he got over it and he ate a whole bunch and did a whole bunch of things. Then he had his next session.

I know other people that had minimal problems, Maybe a little bit tired for a day or two, but that was all.

The results are that variable.

Thanks Jeff.
It's been 10 days now. We hoped he'd be feeling better by now...but still tired and no appetite..
The Oncologist said go to the lab this next week if he still is getting worse. Not sure what that means..
They kind of minimized the side effects when we were told about Pluvicto, but they are worse than chemo.
Thanks for your info...Funny how everyone reacts differently

@cal77 I have taken two rounds of Plavicto with absolutely no side effects so I am not much help. I did chemo before and had the issues you are talking about. As I remember the side effects started to get better in week three, and I was good again when it was time for another round. Best of luck I know this sucks

You're so lucky to have no side effects...
Maybe we will go to the lab this coming week and see what's going on.
It's all so scary..We don't know what to expect or when the symptoms will get better. We don't know if Pluvicto will work. Chemo didn't work...His PSA is up to 800!!!
Yes, it does suck..thanks for your reply..

Hi, Pluvicto did not work for me. PSA continued to go up steadily. I stopped after four shots. My side effects were nausea, loss of appetite, dry mouth, and the worst constipation. Good Luck I hope it works for you. I shall “endeavor to persevere”

@cal77
I am not a doctor so I am not sure if this is really the answer, but it could be that a steroid like prednisone could help relieve some of that fatigue. You definitely want to go in and talk to the doctors. They can come up with something that can help since it has been so long since treatment.

@johnravens
Not sure if you’ve heard that Pluvicto works really well for 33% of people OK for 33% of people and not at all for 33% of people.
If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.

You might want to find out if you have any of these. You should already have gotten an hereditary, genetic test, If not, you should do that first. Then get a somatic, genetic test and see if any of your metastasis have produced these particular genetic problems, The test can be done with the sample of blood. If they are only somatic, they can come and go. In that case Pluvicto Might work in a year or two if the somatic genetic change goes away.

I was one of the lucky dogs last year. My PSA dropped like a rock after the first infusion and again after the second. We pulled the plug at that point and now I have gone a full year - kind of like driving without a gas guage. However, monthly PSA checks indicate that my free ride might be coming to an end and I might be going for another round.
There are no guarantees, and we all react differently. I did double duty chemo (docetaxel and carboplatin) some six years ago. While it sort of worked to some degree, giving me about 6 months, it was a "wild ride" and I would never go back there again. Pluvicto is way bettah in my experience. Good luck.

@jeffmarc Hi,

Is there anything that works to fight Tp53? I am having a port installed on the 12th to start Taxotere. I have read that tp53 is resistant to chemotherapy. I have many bone metastases and a spot on my liver. 4 Pluvicto shots really lowered my platelets. I know the situation is dire and maybe getting near the end but I would really like to hang around with my family for a good bit longer. Thanks for your help and info

@johnravens
I know of no treatments yet for TP53. PTEN treatment is just coming out. The cut back in financing for medical drug development has really hit a lot of this development. All you can do is get out there and vote.

Since you are getting chemo, ask if carboplatin Could make a difference. It works well with a lot of different aggressive cancer Problems. It is supposed to be highly effective with TP53, so I’m wondering why they have not already recommended it.