I hadn't been aware of this particular effect of Hydroxyurea, but I do experience it, especially in summer. Along with it, I become overheated and lethargic. I have permanent reddish rashes on my cheeks, which I had attributed to "mask rash" during and after the pandemic, but it has never gone away, so it may be an effect of the Hydroxyurea. I am about to try an experiment with using cranberry juice instead of Hydroxyrea to lower and control platelet count. It has a number of beneficial effects. Perhaps my rash will go away? Hope so. The main Hydroxyurea effect I hope to rid myself of by not using the drug is the destruction of my red blood cells, so, perhaps the return of my red cells to normal levels will solve the rash.