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ADT or no ADT? What should I ask my Oncolgist?
Prostate Cancer | Last Active: May 28 7:09pm | Replies (50)Comment receiving replies
@zeits53
The muscle and bone deterioration from six months of ADT are not really a big deal. The benefit they can give for preventing the cancer from coming back Can be significant.
I’ve been on ADT for eight years now. I go to the gym three times a week to keep my muscles up and I’ve been on bone strengthener for about the last seven years. Didn’t need them the first year.
I had six months of ADT when I had eight weeks of salvage radiation, I was 64 and didn’t even notice that the ADT affected me. My brother had SBRT radiation at 77 and they gave him a six month Lupron shot. It did give him hot flashes, but that was the only side effect he noticed. They went away about nine months after the shot wore off but got milder as that time went on.
Orgovyx has the least side effects of any of the ADT drugs. The testosterone comes back real quick after you get off of it most people get it back to real good levels after three months.
You’re probably going to benefit a lot more from taking ADT than not taking it. With the relatively high decipher score you have, it would make sense to take it.
Replies to "@zeits53 The muscle and bone deterioration from six months of ADT are not really a big..."
@jeffmarc after further thought I have decided to forego orgovyx: although Gleason is (4+3) 7, it is one core from the roi ( region of interest). 2 cores were 6 and the remaining were negative. Although the Decipher is .68 it is the lower end of the high risk and there were no cribiform clusters on pathology. I had a PSA 4 days ago of 2.4 and previous was 2.2. So to take the hormone blocker in order to increase survivability ( decrease biochemical recurrence) by 5-10% does not seem beneficial. It comes down to if this is a localized lesion that will be cured by SRBT or possibility of micro metastasis that will recur down the road. The side effects are not worth the 5-10% benefit of ADT.
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@jeffmarc thanks so much for your advice. I think I may start Orgovyx and see what the side effects are like. Previous to my pos biopsy I intermittently took testosterone and now having gone 3 months w/o it I am fatigued and the sarcopenia is evident. But if as you, I’m able to continue to the gym ( hiit classes) and accept that I might be able to recover from the side effects, it’s worth a trial.
Do you know anything about the testosterone saturation model?