Newly diagnosed
Hello, I’ve been lurking on this forum since I received the results of my MRI. I’m 73, my PSA jumped from 3.22 to 4.37 in a year. Referred to a Urologist who ran another more complex PSA test which showed a jump, in less than 60 days, to 5.1 with a free PSA of 19%. I had a TRUS biopsy 10 days ago and received the following results during a video call with my Urologist this past Fri, 4/24/26. He is a highly regarded Urologist/Surgeon who has performed hundreds of Da Vinci RPs. He stated that at my age and with my diagnosis RT and ADT would be the better course of treatment.
During the biopsy he took 12 cores, six from each lobe. No cancer found in the left lobe, but 3 of the 6 on the right showed cancer, and a 4th was close. I have a consultation scheduled with an RO, waiting to hear from my MO to schedule. I’m in the Scripps system in San Diego, they have assigned a Nurse Navigator who is helping me navigate the process. I understand that everyone’s journey is different, mine appears as if it might be pretty rocky. I would appreciate any input.
G. Prostate, right medial base, core biopsy:
Prostatic adenocarcinoma, Gleason score 4+3 = 7 (grade group 3) in 1/1 core, involving 25% of the biopsied tissue and measuring 5 mm in length.
Percentage of Gleason pattern 4: 80%
Cribriform pattern present
Intraductal carcinoma
J. Prostate, right lateral base, core biopsy:
Prostatic adenocarcinoma, Gleason score 4+3 = 7 (grade group 3) in 1/1 core, involving 40% of the biopsied tissue and measuring 7 mm in length.
Percentage of Gleason pattern 4: 70%
Cribriform pattern present
Intraductal carcinoma
K. Prostate, right lateral mid, core biopsy:
Prostatic adenocarcinoma, Gleason score 4+4 = 8 (grade group 4) in 1/1 core, involving 20% of the biopsied tissue and measuring 3 mm in length.
Atypical intraductal proliferation
L. Prostate, right lateral apex, core biopsy:
Focal high-grade prostatic intraepithelial neoplasia (PIN)
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@rlpostrp
I did some queries on this, and I cannot find anywhere that they say that there are eight types of cribriform.
There are two basic types invasive cribriform carcinoma and intraductal carcinoma of the prostate (IDCP). Now you can have small or large cribriform But they are the same type just different sizes.
There are some other types that are not really considered Cribriform yet, Atypical Cribriform Lesion (ACL) / Atypical Intraductal Proliferation (AIDCP). Those are types of tissue that they say you should have further biopsies to see if Cribriform is really found.
When I query”are there eight types”, the answer is “No, there are not 8 distinct types of cribriform patterns generally recognized in prostate cancer biopsies.
Current literature and uropathology guidelines, including those from the International Society of Urological Pathology (ISUP), typically classify cribriform prostate cancer into two major, distinct morphological categories based on their invasive potential, which are both associated with poor prognosis and require aggressive management:
PubMed Central (PMC) (.gov)
Do you have a link to this eight types of cribriform?
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2 ReactionsI'll try to create and drop the link, but here is a screenshot of the article title and authors below my list of the eight types of Cribriform that exist:
1. Clear Cell Hyperplasia Cribriform
2. AIDCP Cribriform
3. IDC-dense Cribriform
4. IDC-nuclear artypia (atypia?) Cribriform
5. IDC-comedonecrosis Cribriform
6. Cribriform Pattern 4
7. Cribriform Pattern 5
8. Ductal Carcinoma Cribriform
From MDPI (journal?)
Cribriform Patterned Lesions in the Prostate Gland with Emphasis on Differential Diagnosis and Clinical Significance
by Maria Destouni 1, Andreas C. Lazaris 2ORCID and Vasiliki Tzelepi 3,*ORCID
Department of Cytopathology, Hippokrateion General Hospital of Athens, 11527 Athens, Greece
First Department of Pathology, School of Medicine, The National and Kapodistrian University of Athens, 11527 Athens, Greece
Department of Pathology, School of Medicine, University of Patras, 26504 Patras, Greece
Author to whom correspondence should be addressed.
Cancers 2022, 14(13), 3041; https://doi.org/10.3390/cancers14133041
Submission received: 22 May 2022 / Revised: 14 June 2022 / Accepted: 20 June 2022 / Published: 21 June 2022
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5 Reactionshttps://www.mdpi.com/2072-6694/14/13/3041
Link to MDPI article on the types of Cribriform tissue that exist.
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4 Reactions@rlpostrp
Very interesting. Lots to comprehend.
Thank you for all who have provided me with advice, wisdom, support and compassion, it is greatly appreciated. I had a PET scan yesterday and today received the first good news since I started this journey; the cancer is contained in the prostate capsule. I meet next week with my MO, and my RO the following week. One sentence (see below) in the pathology report I could use some help with. I know it shows where the lesion is located, but not sure if this is a good or bad location, and have no idea what a SUV max 10.7 (axial 317) means. I would again appreciate any input.
Right posterior basal prostate gland ILLUCCIX avid lesion, SUV max 10.7 (axial 317)
@carlsbadguy
It just says there’s a spot on your prostate that has a fair amount of cancer in it.
You are going to treat your prostate, That will take care of it whether you picked surgery or radiation.
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2 ReactionsRegarding Cribriform, like I have mentioned on this forum before the chief pathologist at a COE stated these exact words when asked about cribriform: "In summary, the presence of cribriform pattern is documented in all cancers that have pattern 4"
I just think all pathologist don't report it but should specify it and the type of cribriform if 4+
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2 Reactions@copyman
I’ve heard from hundreds of people that have had fours in their Gleason score, cribriform does not seem to be a common problem. That doctor’s comments seem to be suspect. Never heard that before, that’s for sure.
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