1. < Osteoporosis & Bone Health
Profile picture for tkdesign

Tymlos side effects

Posted by tkdesign @tkdesign, Apr 16, 2025

Does anyone find Tymlos to cause nausea or stomach pain or gerd? I want to avoid any drugs that can worsen GI issues. Already have barretts esophagus and past GI surgery.
How often should calcium levels be checked when using it?

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Profile picture for beatrix16
beatrix16 | @beatrix16 | May 14 1:35pm

I had stomach issues for a few weeks which apparently was bloating. I wasn't nauseous but my stomach hurt after eating. I also did not have much appetite. This occurred in the third month since starting treatment in January of this year. I took Country Life Papaya Digestive Support chewable tablets and that relieved the pressure.

I've had a few other side effects (like tiny headaches) but they have all gone away in 2 - 3 weeks so I think it's just a matter of my body getting used to the drug. I started with a half dose (4 clicks) for the first week but was able to get up to the full dose by the second week. I'm 67 yrs old and weight 128 lbs.

REPLY
Profile picture for willowmena
willowmena | @willowmena | May 18 8:23am
In reply to @dmshope "Thank you for your encourgement. It was a long complex job to try to figure this..." + (show)
Profile picture for dmshope @dmshope

Thank you for your encourgement. It was a long complex job to try to figure this out. The thought is that, for me , the tymlos was building up in the body. I do not process toxins fast or well - hormones, toxins and medications must be processed ( detoxed) in the liver in order to be eliminated from the body. Normally I do not have a probelm , as I eat cleanly, organic, no caffiene, no alcohol, no drugs ( not even tylenol)., no frageances no chemicals.etc. However, tymlos is a hormone and must be processed. Since I am a slow processor, the hormone began to sit in my system and get attracted to sites it could attach to - the pancreatic islets ( loaded with PTH receptors) were my vulnerability and became 'clogged' so the enzymes could not get to the digestive track. I believe I have always had a vulnerabiity there so I dont know if the pancreass continued to be inflammed even while I as on enzymes - but I am now off tymlos and have returned to 'normal' My ayurvedic /naturpathic physician veiws digestion not so much as a stomach issue as it is a liver/gall bladder/ pancreas issue. This is a different prespective than most GI people who seem to assess digestion as always a stomach issue or acid issue. I did not have a stomach problem or an acid problem.
I was very lucky to arrive a solution ( supplement with enzymes and liver support) to manage the pain and digestive issues. It gives us hope that we can learn to handle the side effect that are not severe and do what we need to regain health.

Jump to this post

@dmshope I have chronic pancreatitis in the severe category, diagnosed three years ago well before beginning to take Tymlos. I survive on prescription enzymes without which my weight would drop below 100 pounds at 5‘5“. Tymlos to my knowledge has not affected my pancreatitis at all. In fact, I increased my protein intake dramatically and have managed to gain and keep 6 pounds over the last six or seven months. Tymlos has not increased my pancreatic insufficiency symptoms. No stomach pain or indigestion, no Gerd, and no urgent visits to the restroom. After my insurance denied coverage for Tymlos, I was able to appeal on the basis of the chronic pancreatitis as oral medications were contraindicated. If Tymlos is affecting my chronic pancreatitis in any way there have been no symptoms to indicate that and I would repeat that my pancreatitis is quite severe with Lab numbers to support that diagnosis.

REPLY
Profile picture for dmshope
dmshope | @dmshope | May 18 9:57am

Dear Willowmena
Happy that tymlos has not effected your pancreatitis. That is very good. And I hope it is very beneficial for your bones and life. Since you are already on enzymes , there would be no way of knowing if tymlos was effecting the pancreatic islets to reduce enzyme flow. And it dosent matter either. You are doing well, thank God.
Also glad to hear you have gained some weight, I too have added protein and have been able to gain.

We are all different and in my situation the stomach / pancrease issues did not start until the 8 month of tymlos.It was very hard to diagnosis but once discovered it was an easy fix. PTH receptores are all thruout the body and are abundnat in the pancreatic islets. FOr most peorple this is not a problem.

Stomach issues are a side effect for tymlos - but not a common one,

GOod health to you.

REPLY
Please sign in or register to post a reply.