Are there withdrawl symptoms immediately after stopping Orgovyx?

Posted by ava11 @ava11, Apr 1, 2025

Any of you experienced hot flushes, fatigue or other symptoms worse than prior to stopping Orgovyx?

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Profile picture for dmkplan @dmkplan

Been off orgovyx for 5 days. Very irritable. Cranky. Hot flashes worse than when on it for 6 months. Had to apologize to the wife for really snapping at her. Had to google it to show her it was not intentional yelling. I hope she can deal with until it wears off

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@dmkplan Oh man, same here!! I was a happy idiot on Orgovyx - calm, pleasant and unflappable…
But after about 2 weeks off of it, I was more than cranky! I was quick to anger, tense, ready to argue over nothing!! My wife asked me to go back on it 😂.
I told all of this to my urologist, who remarked that my T came back to 750 ‘really fast’.
“You know”, he began, “That testosterone is what you needed to survive in caveman days…but today? I always tell my two young daughters that the most dangerous thing they will ever encounter in this life is a MAN”
Phil

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Started Orgovyx 31 Dec and ended 24 April right after my TULSA PRO procedure. My original plan was to have radiation and Orgovyx for two years. The lack of energy, weight gain and hot/cold flashes made me seek other options for my cancer. I ended up getting a full ablation of my prostate.

Currently dealing with the loss of urinary control, but that’s the only side effect so far of the TULSA procedure. Small price to pay for not having 45 sessions of radiation and two years of Orgovyx.

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Profile picture for heavyphil @heavyphil

@dmkplan Oh man, same here!! I was a happy idiot on Orgovyx - calm, pleasant and unflappable…
But after about 2 weeks off of it, I was more than cranky! I was quick to anger, tense, ready to argue over nothing!! My wife asked me to go back on it 😂.
I told all of this to my urologist, who remarked that my T came back to 750 ‘really fast’.
“You know”, he began, “That testosterone is what you needed to survive in caveman days…but today? I always tell my two young daughters that the most dangerous thing they will ever encounter in this life is a MAN”
Phil

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@heavyphil

My wife is a nurse. Says to me the orgoyvx saved my life. Psa is .06. Wow. Had the sbrt 5 radiation treatments. Going to reach out hematologist oncologist if the crazies continue

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No side effects from stopping Orgovyx here. It started letting go after 2 weeks and the third week had a glimpse of my normal self. The post radiation side effects were hands down the worst of the bunch and were progressive.

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Profile picture for dmkplan @dmkplan

@heavyphil

My wife is a nurse. Says to me the orgoyvx saved my life. Psa is .06. Wow. Had the sbrt 5 radiation treatments. Going to reach out hematologist oncologist if the crazies continue

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@dmkplan I think it’s just the rebound effect of having zero T for 6 months.
Once I realized WHY I was feeling this way (sub clinical roid rage), I simply took a deep breath, ‘thought’ before I spoke and my responses were much more in line with my usual behavior.
Phil

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Profile picture for heavyphil @heavyphil

@dmkplan I think it’s just the rebound effect of having zero T for 6 months.
Once I realized WHY I was feeling this way (sub clinical roid rage), I simply took a deep breath, ‘thought’ before I spoke and my responses were much more in line with my usual behavior.
Phil

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@heavyphil 6 months down, 6 to go here; I can’t wait for the subclinical roid rage to announce the road to recovery!!

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My experience, no...

Within three weeks of coming off 12 months of Orgovyx, the fatigue, muscle and joint stiffness subsided and went away.

Genitalia shrinkage took around three months.

Damn hot flashes, like fat cells, refused to die and took almost six months to finally go away.

It was about a year to get rid of the weight.

Kevin

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Profile picture for kujhawk1978 @kujhawk1978

My experience, no...

Within three weeks of coming off 12 months of Orgovyx, the fatigue, muscle and joint stiffness subsided and went away.

Genitalia shrinkage took around three months.

Damn hot flashes, like fat cells, refused to die and took almost six months to finally go away.

It was about a year to get rid of the weight.

Kevin

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@kujhawk1978 Thank you for the detail! I finish 18 months of Orgovyx at the end of June and am glad to have some idea of what to expect. I'm grateful that you're on this side of that treatment and I hope to be, too, in another year.

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