1. < Autoimmune Diseases
Profile picture for rutgersmom123

Does anyone have sero negative rheumatoid arthritis?

Posted by rutgersmom123 @rutgersmom123, May 8 1:07pm

Does anyone else have sero negative rheumatoid arthritis? I have neg ANA but increased ESR, crp, and ccp positive for rheumatoid

Interested in more discussions like this? Go to the Autoimmune Diseases Support Group.

Profile picture for dachshundmom
dachshundmom | @dachshundmom | May 9 5:20pm
In reply to @sueinmn "@rutgersmom123 May I ask if you have seronegative rheumatoid arthritis? Are you seeing a rheumatologist for..." + (show)
Profile picture for Sue, Volunteer Mentor @sueinmn

@rutgersmom123 May I ask if you have seronegative rheumatoid arthritis? Are you seeing a rheumatologist for treatment?
Sometimes it takes a few tries to find a doc who accepts that about 20% of RA is sero-negative and treats it. I have had symptoms for about 20 years and self-managed until 2025, but finally my body would no longer tolerate NSAID's. My pulmonologist, of all people, sent me to a wonderful rheumatologist, and we are still working on getting the beast under control.

Jump to this post

@sueinmn I

REPLY
Profile picture for dachshundmom
dachshundmom | @dachshundmom | May 9 5:21pm

I also have thyroid disease. Started as hyperthyroidism killed it went hypothyroidism. So the fatigue from both RA and that is unreal.

REPLY
1 reply
Profile picture for pb50
pb50 | @pb50 | May 10 6:12am

Many are sero negative. I was for 7 years until A new Rheumatologist did the test to prove my arthritis was osteo. Surprised both of us that it was positive. So it can be negative and it can also change.

REPLY
Profile picture for Alta Net
Alta Net | @altabiznet | May 10 10:49am
In reply to @chpfireball "I was diagnosed with PMR 2.5 years ago. Rheumatologist started me on Prednisone. I tapered down..." + (show)
Profile picture for Shirley K @chpfireball

I was diagnosed with PMR 2.5 years ago. Rheumatologist started me on Prednisone. I tapered down to 0 in 14 months and my hands swelled up and hurt so bad I couldn't make a fist. My grip strength was down to 15 pounds. Blood test were all normal. Rheumatologist said I was having a relapse and put me back on Prednisone. Grip strength up to 60 lbs. Tapered down to zero and hands reacted the same way. Doc said she thinks I have sero negative rheumatoid arthritis and put me on Methotrexate and Naproxen. After six weeks hands still swollen, but a little less pain. I also developed a rash on my wrist. Have had skin problems approx 10 years ago and not much since. Not doc is testing for psoriatiac arthritis and added hydroxychloroquine. I'm a 62 year old female retired police officer.

Jump to this post

@chpfireball

I also had skin rash all over my body in response to methotrexate in addition to brain fog and fatigue. More advanced biologics like adalimumab (Humira), tocilizumab (Actemra), and Rituximab may work better. You may want to check with your doctor. Now cheaper biosimilars for these drugs are also available and are covered by insurances.

REPLY
1 reply
Profile picture for Alta Net
Alta Net | @altabiznet | May 10 10:51am
In reply to @dachshundmom "I also have thyroid disease. Started as hyperthyroidism killed it went hypothyroidism. So the fatigue from..." + (show)
Profile picture for dachshundmom @dachshundmom

I also have thyroid disease. Started as hyperthyroidism killed it went hypothyroidism. So the fatigue from both RA and that is unreal.

Jump to this post

@dachshundmom

What treatments are on?
I also have hypothyroidism with Hashimoto's, inflammatory arthritis and scleroderma.

REPLY
Profile picture for Shirley K
Shirley K | @chpfireball | May 10 12:02pm
In reply to @altabiznet "@chpfireball I also had skin rash all over my body in response to methotrexate in addition..." + (show)
Profile picture for Alta Net @altabiznet

@chpfireball

I also had skin rash all over my body in response to methotrexate in addition to brain fog and fatigue. More advanced biologics like adalimumab (Humira), tocilizumab (Actemra), and Rituximab may work better. You may want to check with your doctor. Now cheaper biosimilars for these drugs are also available and are covered by insurances.

Jump to this post

@altabiznet
Thank you!

REPLY
Profile picture for fairn
fairn | @fairn | May 10 4:47pm

My RA factor has been negative, but an elevated CCP, positive ANA and clinical symptoms (obvious joint damage to my right hand) led to a diagnosis of RA. Due to other clinical symptoms I've also been diagnosed with Sjogren's.

REPLY
Profile picture for trishrip
trishrip | @trishrip | May 11 5:02am

I have seronegative RA, as well as seronegative Sjogren's. I am on Simponi monthly injections and hydroxychloroquine.

REPLY
Profile picture for wstacy
wstacy | @wstacy | May 11 9:26am

I am zero-negative RA, sero-negative Sjogren’s, Raynaud’s and Behcet’s. It’s quite an autoimmune cocktail to live with. I also have CHIP and can’t seem to keep hemoglobin. Headed to Mayo on Saturday. Hoping to get some new insights.

REPLY
Profile picture for rutgersmom123
rutgersmom123 | @rutgersmom123 | May 12 11:51am

You know, this whole autoimmune thing is a mystery. I started getting issues right after I was sick with meningitis . I have since read that a viral infection can kickstart autoimmune disease. Since then, I have aded several autoimmune diseases. I have been on many medications including biologics for quite a few years. My doctor is now thinking about doing immunoglobulin therapy. I am not sure what to do as I am not feeling too bad. I am currently on Rasuvo once a week and taking Tylenol and using prescription topicals for rashes. I feel reasonably well enough. Will have to think about this.
Have a good day all.

REPLY
Please sign in or register to post a reply.