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new study on cardiovascular risk of ADT

Posted by melvinw @melvinw, May 6 4:39pm

Tripped across this JAMA Cardiology abstract the other day and just sharing as an FYI. The big takeaway:

- in this trial, men on relogulix faired significantly better than men on leuprolide in terms of coronary plaque progression

The comment by Edoardo Cervoni, MD is also worth reading. To quote:

'The REVELUTION trial represents a critical step in understanding how treatment pathways influence patient outcomes beyond cancer-specific mortality. Future studies evaluating prostate cancer screening and management should incorporate mechanistic and patient-centered endpoints, including cardiovascular morbidity and quality of life, to ensure that interventions truly extend meaningful survival without shifting risk from one cause of death to another.”
https://jamanetwork.com/journals/jamacardiology/article-abstract/2845162

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

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thmssllvn | @thmssllvn | May 7 10:41am

An artificial intelligence review of biopsy slides by ARTERRA can make a comparison with over a thousand others. Adding a second ARPI drug to the chosen primary ADT is evaluated looking back into their data files. They can suggest that for +/- 25% adding ZYTIGA (abiraterone)it is beneficial; whereas for +/- 75%) it is not beneficial. No comment was made about the 3 other ARPIs including XTANDI (enzalutamide).

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Jeff Marchi | @jeffmarc | May 7 11:39am
In reply to @readandlearn "Interesting. I recently moved from Lupron to Orgovyx for other reasons. I also moved from Abiraterone..." + (show)
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Interesting. I recently moved from Lupron to Orgovyx for other reasons.

I also moved from Abiraterone to Nubeqa because I thought that my high blood pressure (190+) on hormone therapy was due to the Abiraterone (my BP for six decades before & after hormone therapy was always 123/78). I had to add Losartan to the Abiraterone to lower my BP.

I have not been on Orgovyx/Nubeqa long enough to know my new BP.

I am glad to be off of Prednisone.

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@readandlearn
I had the same problem you had with abiraterone. I never had high blood pressure. My blood pressure was always normal. Abiraterone Gave me high blood pressure. I am on three different medication’s twice a day six years later losartan, Diltiazem and metoprolol. It also gave me four afib events. My oncologist said no more abiraterone, And I switched to Darolutamide Which doesn’t seem to affect my blood pressure at all.

I always warn people to watch out for abiraterone If they have any heart issues. I don’t one guy that Was on it for five years and said it caused no problems. About a year later, he had to have open-heart surgery. Not saying Abbie had anything to do with it, but it sure seemed like it did not help.

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surftohealth88 | @surftohealth88 | May 7 5:35pm
In reply to @northoftheborder "@surftohealth88 The funny thing is that in Canada, they priced Orgovyx exactly the same as Firmagon..." + (show)
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@surftohealth88 The funny thing is that in Canada, they priced Orgovyx exactly the same as Firmagon (about US $215/month) and comparably to Lupron on a month-by-month basis, so it shouldn't make a difference to the provincial health ministries or private insurers. The only reason to keep prescribing the older, injectable ADTs are

1. A patient with dementia who might not remember to take a daily pill.
2. A patient who (for some reason) might react badly to GnRH antagonists.
3. Lack of awareness of the availability of Orgovyx as an alternative (it became widely available here only in 2024).

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What is the least guarded part of the border ??? 😆

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jim18 | @jim18 | May 7 5:55pm
In reply to @surftohealth88 "What is the least guarded part of the border ??? 😆" + (show)
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What is the least guarded part of the border ??? 😆

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@surftohealth88 The Canadian online pharmacies are selling Orgovyx for about $100 above local prices ($300-$320) plus any current tariffs. Ogovyx is shipped from Canada. Many drugs ship from Mauritius but they also source from UK, NZ, India, and Australia. US typically allows up to 90-day supply for personal use at the border or through the mail.

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surftohealth88 | @surftohealth88 | May 7 8:21pm
In reply to @jim18 "@surftohealth88 The Canadian online pharmacies are selling Orgovyx for about $100 above local prices ($300-$320) plus..." + (show)
Profile picture for jim18 @jim18

@surftohealth88 The Canadian online pharmacies are selling Orgovyx for about $100 above local prices ($300-$320) plus any current tariffs. Ogovyx is shipped from Canada. Many drugs ship from Mauritius but they also source from UK, NZ, India, and Australia. US typically allows up to 90-day supply for personal use at the border or through the mail.

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@jim18

Oh, thanks so much for the info !!! Much obliged 💖 !!!

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jime51 | @jime51 | May 8 6:10am

Thanks very much! Strokes are common in my family; less plaque is better! https://clinicaltrials.gov/study/NCT05320406

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