Before trying a new drug, please check out LDN - low-dose naltrexone, which I started taking in early 2025. It helped me tremendously by relieving my pain and ending my severe insomnia. It's safe and had no bad side effects for me, except for vivid dreams (not nightmares tho). Drawbacks are that you must get your prescription filled at a compounding pharmacy, it's not covered by insurance, and it takes a few months to work up to the maintenance dose and then can take a couple months to notice benefits. Also, I read that it doesn't benefit everyone. It costs me $115 for a 3 month supply.

Here's one article on it, there's any more on-line: https://www.verywellhealth.com/low-dose-naltrexone-ldn-for-fibromyalgia-cfs-716070

My constipation was cured when I started taking 250mg of magnesium glycinate every night an hour before bed. I started it because it relaxes muscles and helps with sleep. But it also cured my constipation. Before that, I had to take Miralax every day.