@gently Being male, I think my marker levels are completely different (lower?) than some other people here. These are some readings from the past:

Pre-Tymlos: CTX 242, P1NP 45
At 18months: CTX 165, P1NP 67 (this was highest P1NP ever reached)
At 24 months: CTX 202, P1NP 53

At the end, it was clear that Tymlos effectiveness was waning (confirmed by DEXA.). But, you can see that my P1NP never got to the really high levels that others have had, yet I had tremendous gains in bone density (18% in total.) We'll see what the new values are after four months on Fosamax.

My wife has very different numbers.

Pre-Tymlos: CTX 889, P1NP 93
At 3 months: CTX 1700, P1NP 310

Her bone-building process has really ramped up. She also had a partial thyroid removal during this time, so it's possible that the thyroid nodules that were removed were affecting her hormone levels and contributing to her osteoporosis. Between the surgery and the Tymlos, her bone turnover process has changed a lot.