Hi @mpg51 I did a search in Connect to find other members for you with Mantle Cell Lymphoma. Rituximab and Calquence (sometimes paired with venetoclax) from my understanding are standard treatments for CLL/MCL.

I wasn’t sure which discussion to share with you so I’m providing the link to the search results:
https://connect.mayoclinic.org/search/
I can empathize with you about the spleen discomfort and loss of appetite. When I was going through my leukemia ‘drama’ the sense of fullness, loss of appetite and sometimes interference with deep breathing was so frustrating. Eventually the spleen should shrink as treatments continue. Keeping hydrated can really help flush the organs. I mentioned to someone else that I found drinking room temperature water allowed me to drink more water to get my daily intake.
Did you have the typical reaction to the first round of Rituximab?