I have had my share of negatives while on Fosamax. I have IBS and Fosamax has made my intestinal issues a lot more sensitive than before taking this medication. I have learned what I can and cannot tolerate while on Fosamax and avoid those foods. Usually I am very tired the day I take the dose but feel better the next day. Here is my dilemma. I already have had a year on Evenity and needed a new med after the 12 month course. After learning about possible side effects of Prolia and Reclast, I just could not take the chance. I am 75 years old and am afraid my remaining years could be devastating with the possible side effects of these drugs that stay in your system for an extended period of time. At least with Fosamax, you can stop the drug at any time. I am not thrilled with Fosamax but the way I see it, all osteoporosis drugs have theirs cons so which of all these is best for your situation? Too bad a safer medication with less severe possible side effects is not available.