Tymlos Sleep Disturbance Side Effect When Titrating Dose

Do you take the medication at night? Supposedly, it is more effective in the morning since you are up and about the entire day.

@njx58 My first three full injections were in the morning, but I had significant side effects in my provider wanted to discontinue the medication. I pushed back and said I wanted to first try it at night. I was not able to sustain on a full dose and went back to half a dose, at night, with a plan of trying to get back to pull this. I am choosing to increase every 10 days. My body definitely has pushed back at each increase, so we will see if I can stick to the plan or not. So far, I am making it work. Nobody is sure why I started to develop quarter-sized welts that lasts for 5 to 7 days on my stomach at injection #24 forward. It would have made more sense to have that kind of reaction from the beginning, as opposed to starting 3 weeks later. Mitigating everything to the best of my ability in order to stay on the medication.

Not sure about the insomnia? I take mine in the morning though about 15 minutes before eating, as I find it makes me hungry, also moving around for me is good.
My doc was fine with titration. Also some days when I have something major I will titrate down a couple of clicks.
I too get the welts. It seems to me, for myself, it’s related to having very little belly fat as well as injecting cold medicine. If you find a solution let us all know! Several of us don’t seem to have much space between bell button and other scar type issues so small area to actually inject.

@ccps101 I do not inject cold medicine. Mine is kept on the shelf for the 30 days. The only thing I found that seems to help the welts, after I noticed a bead of medicine at the tip of my needle before injecting (on a regular bsais) is to gently touch the tip of my needle to a piece of Kleenex in order to absorb that drop. I'm thinking once the skin was punctured, that drop is what was irritating skin and causing the welts (?). It seems to have reduced the severity of my welts big time. I have just recently started doing this, so I don't know if it will help long term or not.

Low belly fat is not an issue for me. I use the chart on the Tymlos erasable board and a 2" radius circle with "clock markings" to help guide me to more precise injection locations. Once I was comfortable with how I laid out 30 days worth of injections on the belly chart, I took a picture, erased the numbers, and rewrote them using a permanent Sharpie. That way I can try to keep my rotation consistent each month. I do not want to intentionally aggravate welts anymore than necessary.

@cathyf31 Re: welts, one thing I noticed was that experimenting with the shorter 5 mm needle left marks as opposed to the 8 mm needle. My wife, on the other hand, does fine with 5 mm. Sometimes a simple change like that makes a difference.

@njx58 Thank you!! I will keep that in mind. I currently use a 5 mm.