@marymad
I had no side effects from the Hiprex. I think I took it with a couple of crackers for the first couple of weeks and then on an empty stomach for the morning dose. I use applicators for the estradiol. You can purchase disposable ones on Amazon which are really affordable. Cleaning the ONE that comes in the box is not practical. The doc said I could just put it on my finger and insert it that way too but I chose the applicator. Good luck 😄.