P1NP number on Tymlos

Posted by marymj7 @marymj7, Jan 1, 2024

After 3 months on Tymlos, my P1NP bone marker has increased by 50% to 109. I was initially excited, but am wondering if this is excessive. Anyone else had numbers like this?

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Profile picture for yogagirl57 @yogagirl57

Hello fellow Tymlos takers! I have been on Tymlos for 3 months, and I am also trying to figure out why my CTX went from 196 last year to 895.8 this month of April. My P1NP is 175. Of course I contacted my Endo and she was not alarmed even a little! Can you believe this? Would love to know your thoughts……

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@yogagirl57, were you on an antiresorptive before Tymlos.

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Profile picture for gently @gently

@yogagirl57, were you on an antiresorptive before Tymlos.

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@gently No I wasn’t on anything before.

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Profile picture for kfhoz @kfhoz

@yogagirl57 See the below video by Dr. Doug Lucas. I went through it slowly, with the transcript enabled, in order to try to understand my CTX and P1NP. From my interpretation, what you may have is an indication of good bone turnover in the BUILDING direction.

After you watch this and do your calculations, please let us know what you think. I would like to know whether the number 195 means anything to you personally then, as a check on what I understood from this presentation. I plan to write up my own experience with CTX & P1NP tests soon.

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@kfhoz thank you. Look forward to watching.

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Profile picture for yogagirl57 @yogagirl57

@gently No I wasn’t on anything before.

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@yogagirl57
CTX rises on Tymlos, your rate is surprising. Before worry, though, consider lab or transcription error. CTX has risen as high as 49% in studies where exercise is performed prior to the test. And CTX levels change throughout the day.
What was your increase in P1NP.
Lastly, fracture can increase CTX by 69%, but don't even think about that, unless you have new pain, until you repeat the CTX marker.
I can never wait for the next doctor appointment and frequent Jason Health https://www.jasonhealth.com/
qt17406 Collagen Type I C-Telopeptide (CTx) $50.00
Lab Collection Fee $18.00
Grand Total $68.00
Your doctor has a full view of your medical situation and isn't concerned, which should be relaxing, but can put a person on greater alert. She is prescribing the best medication and so deserves trust.
I don't even have a basic medical background and am hoping you went to the gym before your draw.
,

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Profile picture for gently @gently

@yogagirl57
CTX rises on Tymlos, your rate is surprising. Before worry, though, consider lab or transcription error. CTX has risen as high as 49% in studies where exercise is performed prior to the test. And CTX levels change throughout the day.
What was your increase in P1NP.
Lastly, fracture can increase CTX by 69%, but don't even think about that, unless you have new pain, until you repeat the CTX marker.
I can never wait for the next doctor appointment and frequent Jason Health https://www.jasonhealth.com/
qt17406 Collagen Type I C-Telopeptide (CTx) $50.00
Lab Collection Fee $18.00
Grand Total $68.00
Your doctor has a full view of your medical situation and isn't concerned, which should be relaxing, but can put a person on greater alert. She is prescribing the best medication and so deserves trust.
I don't even have a basic medical background and am hoping you went to the gym before your draw.
,

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@gently I can’t remember now if I went to the gym prior, and had no idea that I shouldn’t exercise prior to the test. I am very active and do cardio and weights alternating days so I’m sure that I did one or the other; but it would have been the day prior since I had the blood test early in the morning. How long should you hold off exercising prior to the test? I guess I’ll have to wait for the results for the next test in 3 months. I just thought that increase was crazy ; but, again. , my Endo seemed very unconcerned. I do not have a baseline on P1NP . That was the first time I had been tested.

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yogagirl157, Unrelated studies indicate that the usually persists for 4 hours. Test before morning exercise, but not before 8am. Weights and cardio are know to raise CTX. That's a relief.

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