Gabapentin - being linked to increased risk of dementia
According to a large scale observational study published in the journal "Regional Anesthesia & Pain Medicine", patients who received frequent gabapentin prescriptions were significantly more likely to develop dementia and/or mild cognitive impairment (MCI).
Researchers analyzed anonymized medical records from tens of thousands of Americans sourced from TriNetX, a federated health research network with electronic health records from 68 healthcare organizations across the country.
They found that patients whom had received six or more gabapentin prescriptions were 29% more likely to be diagnosed with dementia and 85% more likely to be diagnosed with MCI within 10 years of their initial pain diagnosis.
There is more - To view the full report:
https://doi.org/10.1136/rapm-2025-106577
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@lindasrk11 I was first prescribed gabapentin when I first experienced calf/leg pain. The pain starts when I get up in the morning till I go to bed at night. Walking, standing and even sitting hurts . It's just lingering . At least I can sleep at night. I've tried all kinds of pain meds, can't tolerate any form of opioids. I'm very sensitive to meds. I really hoped that the back surgery would correct whatever issues I had with my spine, but it did not. Prior to that I had at least 5 years of this pain, and surgery was the last resort. I really want to wean off gabapentin. Did the spine surgery fix your sciatica problem?
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1 Reaction@mayofeb2020 My fusion was L-4 to L-5 and L-5 to S-1. Those are the levels that primarily affect your legs. The pain radiated from my back, through my glutes to my thighs but only to my knees. It did not affect the knee or below. (Nothing but epidurals gave me any relief, and I can't tolerate opioids or some muscle relaxants so I was in the same boat.) The fusion DID fix my sciatica. My spine doctor did a cervical fusion for me in 2016, so I'd been seeing him for 10 years. He'd been keeping an eye on my lumbar spine since i see him every year for my neck anyway. He knew my exercise schedule (every day) and told me to keep it up until the sciatica showed up. He gave me the epidurals and that's the first time surgery even came up. Even though I know him well, I still got a second opinion. Then I made him show me the scans and walk me through them. I also have stenosis in L-3, which he widened during the surgery but it continues to deteriorate. My spine issues are caused by arthritis, not osteoporosis or any other conditions. Have they looked at your lower lumbar spine? I assume they've ruled out blood flow issues like PAD and they've done MRI's on your calves to make sure you don't have muscle injury. You may also want to explore amitriptyline (Elavil). or other anti-depressants with your doctor. They gave me amitriptyline for my vertigo to calm the nerves in my neck and amazingly it worked. I'm totally spit-balling here but I did a lot of research on why the amitriptyline worked for my vertigo. All that reading proved to me that the medical and scientific community still don't fully understand brain chemicals. This is a lot to digest and I am not qualified to be giving any advice--it's just my own experience. In the meantime I would try the TENS unit. If an over-the-counter TENS unit helps even a little, even that will tell your doctor something (there are stronger TENS therapies.) I really hope one of these works for you.
@lindasrk11 yes, I had ultra sound on my legs and I have good blood flow so no PAD. I did not have any MRI on my calves. I've talked to people with sciatica that have surgery very great success. My Ortho doctor said I have degenerated discs and my bones are very "soft". I also have arthritis too. I have also gleaned from Consumer Labs that there was a controlled study on people using Benfotamine for neuropathy with some success. I may just try that. I had the surgery with the hope that it would fix my calf pain but I'm really disappointed. Well, I guess there's no guarantee to anything. He was highly recommended. A neighbor's son was having so much trouble with walking
Kaiser told him there's nothing they can do , he'll have to be in a wheelchair for the rest of his life. He went to my surgeon and he is now walking around! I'll try anything at this point.
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