@daisy17
For me, starting at the 1.5 mg dose, it worked for me immediately, but I will say that it is incredibly important which filler your compounding pharmacist uses. I think that is the difference between my feeling well immediately, and those who say it has to get into system.

I have tried other fillers because I am an IBS person, but when tried the others, I didn't feel a thing, so I think that is why fillers matter as they say at LDN Research Trust, because some fillers actually interfere with the effectiveness of the medication. I tried Avicel and glycine and felt nothing, and went back to my pharmacist who compounds with lactose; so I have had to come to the conclusion that FILLERS DO MATTER; as some can actually interfere with the effectivenss as I had read.

I am at 3.0 mg now and not even sure I need to go any higher.