Has anyone on letrozole experienced extreme fatigue?

Hold the press????? I just got the results of a blood test confirming hypercalcemia and high levels of parathyroid hormone. These results may or may not be related to Breast Ca. Further investigation needed I guess. However the point in posting this is to note that hypercalcemia symptoms can include fatigue, insomnia/interrupted sleep, bone pain ( I think?) brain fog, depression etc etc ( among others). So at the moment I cannot tell how many of the symptoms I just listed can be attributed solely to letrazole....More to come I expect.

@judithgrossman good to explore all avenues before jumping to conclusions. I hope you get good answers and start to feel better soon!

First, thanks to all who are sharing their stories here; I just joined this group.

I'm sorry for the Letrozole symptoms that we're sharing -- only glad not to be alone. Three weeks ago, I switched from Anastrazole to Letrozole and am continuing the side effects that prompted me to switch. (I was on Anastrazole for roughly the first month following my mastectomy.)

Regardless of how deep/how long the night's sleep is, I'm exhausted shortly after getting out of bed. Solid naps are great, but it doesn't take long before I'm exhausted all over again.

Because I've seen no positive change in my energy level, I'm likely to discontinue the medication -- unless there might be something to counter the fatigue.

All the best to those finding their way through this and other symptoms.

I’ve been on Letrozole for about a year. I was dealing with insomnia while on it, but found switching to take in the morning has helped. I have bad knees, so I “jog” in the pool for an hour each day to get in my exercise and that has definitely helped with the fatigue and bone loss prevention. Brain fog is something I struggle with as well as what seems to be instant aging/wrinkles in my face. I’m 56 and in the last year on Letrozole my face has aged 10-12 years. But honestly just thankful to be here to share! Hang in there everyone! You’re an overcomer!

Hello All
I am writing in response to my Mar 19 "Hol d the Press" post regarding hypercalcemia.
I had my hopes up too high that a dose of Zometa suggested by oncologist to address high calcium would also make a dent in my fatigue in particular. I had an infusion of Zometa at the end of March. ( Starting 12 hrs plus after the infusion the next day was awful with aches and pains and flu-like sensations all over . Lay still on the sofa and loaded tylenol and advil. Side effects vanished within 36 hours . I have also heard that one feels worse after the initial infusion than after subsequent ones. ) Back to the story at hand. Unfortunately the infusion made no dent in fatigue levels or MSK pain levels. It may have impacted what I might refer to as the emotional "tone" of my depression . But that is a sweeping and general claim that I am not certain of. Meanwhile I can't get anyone to test my blood for calcium levels to see what kind of a dent the Zometa in that. GP won't do it because she did not prescribe infusion and I can't get through to oncologists. complicated system here in Alberta. However I am going to see them May 7 (if I don't have to skeedoodle out of town to see my mother who is 96 and ailing in hsopital in Ontario)...... Fun fun fun. Had axilloa node removal April 9 healing OK but that incision is in such a rotten location, and it is larger than the lumpectomy incision. It is always being irritated and rubbed under my arm. Sure there is a seroma there but hoping it might shrink on it's own.

Well that was all a gush of TMI. Just wanted to report on the fact that my Zometa infusion did not have the miraculous impact on fatigue and MSK problems that I had fantasized it would.

@cmb93 hi there. I have been on it for a year as well. Have all the stuff you are dealing with. I forget what I am saying in middle of conversation. I think my face has aged 10 years as well. I am tired all the time and wake up in the middle of the night every night. I will try taking it in the morning as you do and see if that helps. thank you for your post.