Effexor Tapering Off and Side Effects

Posted by gaile12 @gaile12, Aug 22, 2022

I am tapering off Effexor after being on it for over a decade. I've noticed my stomach gets queasy & I have digestion issues. Has anybody else had this problem?

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Profile picture for daveshaw @daveshaw

@frouke Medications are a real pain but nothing is worse than depression.
Can you imagine what it was like before SSRI’s came on the scene?
Find an SSRI that works and enjoy your life. Depression is a real disease that affects millions of people.

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@daveshaw I know you’re right about that, I usually get frustrated with the side effects and and give up trying but I’m determined to persevere with the new medication and keep my fingers crossed for some good results, thank you for your help Dave.

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Profile picture for vicdenlee @vicdenlee

I need encouragement and hope from those who have experienced side effects from tapering off effexor and how long you were on it, how long it took to taper and how long it took for all side effects to go away!
I am struggling to stay motivated and encouraged to push myself to move through the day! I am anxious when I wake and anxious when I go to bed. I am journaling, praying and trying to use MUSE for relaxing/calming my breathing due to anxiousness. I have an appointment with a psychiatrist, but it is a month away due to availability.
I discontinued the effexor after tapering off 75mg after 17 years due to some increased side effects I was concerned about. I was originally put on it when I experienced some peri-menopause symptoms--extreme night sweats, moodiness, anxiety and panic attacks in my late 40's.
After the last day of tapering(a very short taper unfortunately as the doc I saw convinced me my dose was so low all these years that the side effect would be minimal if non-existant.). I experienced terrible flu symptoms--nauseousness, chills, sweats, dizziness, headache, lack of concentration, etc. Luckily the headaches went away and after 8 weeks I now feel like I can concentrate some better. The chills and sweats are lighter and not as frequent. The nauseousness is not good. My husband baked oatmeal scotchies this morning and the sweet surgary smell made me gag! I am mostly anxious--what will go wrong, how to relax? I feel like I need something to tone this down but not sure what to ask for. Doc suggested yesterday, I combined hydrochloride and busipar to relieve the symptoms. Not sure I trust him since he said I wouldn't have any side effects and didn't want to listen to my concerns about withdrawal side effects in the first place. Even the pharmacist I spoke with indicated my dose was so low it would be really easy to taper off. I am sleepy but don't want to go to sleep during the day so I can make sure I sleep at night.
I was crying quite frequently at almost anything sad, even thinking anything sad. Emotions are dysregulated. I am trying to exercise more, drink more fluid, take my vitaming D which is extremely low due to being on the effexor so long.
Today, I filled out a bunch of paperwork and felt pretty good glued to the chair and concentrating on getting it done, but the minute I knew I needed to make lunch or get up to interact with others, or just think about the symptoms of this withdrawal, I become anxious and lose concentration.

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First, find a different doc. That doc isn't very informed. Symptoms should gradually start to fade. You might notice that they come and go. The pattern will be that intervals between symptoms showing up will start getting progressively longer. Eventually, they will just stop when your brain has recalibrated to the new normal of no meds.

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Profile picture for trenxt @trenxt

I was on 112.5mg of XR for chronic pain. I started to taper from it over 20 weeks ago by cutting every 2 weeks. It was changed to IR in liquid form and I split it into 3 doses a day. Problem is I never did the math on how much the psychiatrist was cutting every time. I wasn't having issues at first as soon as I came down to around 60mg I'm getting stomach pain constantly, lost weight because can't eat due to pain, insomnia is horrible 3 4 days no sleep. I'm at 31mg and I can't keep going like this. I did the math and if I ask for an adjustment to cut 10% of the last dose every 2 weeks will take me another year or so to get off this horrendous drug. Is there a way I can ask to be given another medication that can cover effexor so I don't have to take it anymore and taper off that other one then. This is too painful.

Will I face withdrawal if I cross to another antidepressant? Please inform me.

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I want to taper effexor from 175 to 150. My taper from 187.50 was tough. Would 25 mgs. be too much?

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Profile picture for briacirs @briacirs

I want to taper effexor from 175 to 150. My taper from 187.50 was tough. Would 25 mgs. be too much?

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The recommended reduction is no more than 10% of your current dose, less if need be (see Mark Horowitz or Anders Sorensen).
Just to clarify, you say that your drop from 187.5 to 175 was tough, which is 12.5 mg. Now you want to reduce by 25mg and wonder if it's too much? Maybe I'm missing something.
As someone who ended up in the ER from a too-fast taper, I urge you to take your time.

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Profile picture for briacirs @briacirs

I want to taper effexor from 175 to 150. My taper from 187.50 was tough. Would 25 mgs. be too much?

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I have to agree with @mmsm, you are setting yourself up for misery, I’m going through hell because of tapering too fast from Paxil and I don’t want to try another antidepressant to see if it helps, these meds have helped a lot of people but they have also caused so much suffering for others, I regret having taken them in the first place because I feel worse now than I did before. Please take your time and get off them very slowly if that’s what you’re doing, the alternative is miserable.

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Profile picture for frouke @frouke

I have to agree with @mmsm, you are setting yourself up for misery, I’m going through hell because of tapering too fast from Paxil and I don’t want to try another antidepressant to see if it helps, these meds have helped a lot of people but they have also caused so much suffering for others, I regret having taken them in the first place because I feel worse now than I did before. Please take your time and get off them very slowly if that’s what you’re doing, the alternative is miserable.

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I was hoping to taper off venlafaxine by using Efexor, it's name here in UK. But pharmacists have told the psychiatrist that it is not suitable for tapering because the beads inside the capsules are too variable. Each capsule approximates to its stated dose but those tiny spheroids inside differ from one another.
Has anyone come across this as a problem?

And when tapering do you count them out or weigh them?

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Profile picture for briacirs @briacirs

I want to taper effexor from 175 to 150. My taper from 187.50 was tough. Would 25 mgs. be too much?

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Hi , don’t do the taper fast. You need to let your body adjust . Cut the 25 mg. tablets in 1/2. You still may feel an adjustment but not as bad. It’s normal to want to go fast but it is not a race. Everyone is different but slow and steady is much better. Good luck 🤞

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Profile picture for mitch4444 @mitch4444

Hi , don’t do the taper fast. You need to let your body adjust . Cut the 25 mg. tablets in 1/2. You still may feel an adjustment but not as bad. It’s normal to want to go fast but it is not a race. Everyone is different but slow and steady is much better. Good luck 🤞

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@mitch4444
Sorry I missed the part about pills not being splittable. Ask the pharmacist if they do liquid form of the medication.

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Profile picture for cistus @cistus

I was hoping to taper off venlafaxine by using Efexor, it's name here in UK. But pharmacists have told the psychiatrist that it is not suitable for tapering because the beads inside the capsules are too variable. Each capsule approximates to its stated dose but those tiny spheroids inside differ from one another.
Has anyone come across this as a problem?

And when tapering do you count them out or weigh them?

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@cistus I weigh the small beads because they are so variable.
And venlafaxine and Efexor are the same medication.

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Profile picture for trenxt @trenxt

I was on 112.5mg of XR for chronic pain. I started to taper from it over 20 weeks ago by cutting every 2 weeks. It was changed to IR in liquid form and I split it into 3 doses a day. Problem is I never did the math on how much the psychiatrist was cutting every time. I wasn't having issues at first as soon as I came down to around 60mg I'm getting stomach pain constantly, lost weight because can't eat due to pain, insomnia is horrible 3 4 days no sleep. I'm at 31mg and I can't keep going like this. I did the math and if I ask for an adjustment to cut 10% of the last dose every 2 weeks will take me another year or so to get off this horrendous drug. Is there a way I can ask to be given another medication that can cover effexor so I don't have to take it anymore and taper off that other one then. This is too painful.

Will I face withdrawal if I cross to another antidepressant? Please inform me.

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I read the replies to medication advice with some trepidation. Antidepressants are such a mixed bag of variables from start to finish. They work wonders for some, devastate others. Some people can come off easily, some it's a nightmare. Dr's, Psychiatrists, Therapists help, of course .... but the reality is that the brain is SO complex, barely understood and different in absolutely everyone. With no substantive tests to measure any of the "chemicals" in our brains, it is all a slightly guided crap shoot. Everyone's journey is different.
I have been on Effexor 150mg for 22 years & Celexa 20mg combined. Most of the time my MDD was well managed and life was good.
A sudden an complete relapse on Dec 7th now has me venturing down the path of finding that stability again.
I've increased Effexor to 225, no progress, then a couple of weeks ago went to 300, which was clear to me and my body, WAY to much. It's a bumpy, terrifying, anxiety filled road to travel.... I have to commit myself to doing whatever it takes to live in the light again....

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