Vitamin K: High Doses of MK-4 and MK-7 Show Promising Results

Posted by daisy17 @daisy17, Apr 7 12:07pm

It seems as though doctors in the U.S. focus primarily on medications to treat osteoporosis, many of which have undesirable side effects.

I find it curious that doctors never seem to mention taking high doses of Vitamin K, which has few side effects and has shown promising results in Japanese studies that indicate vitamin K2, specifically MK-4 and MK-7, may improve bone health. MK-4 has been prescribed for osteoporosis in Japan because studies there showed it had benefits in bone density and strength.

Based on this information, I recently started taking 180mcg of Menaquinone-7 (MK7) TrueVantage brand and 45,000 mcg (45 mg) of vitamin K2 (menaquinone-4) - Life Extension K2 High Potency brand.

AI Assist says that it's okay to take both forms: “Taking vitamin K2 in both MK-4 and MK-7 forms together can be beneficial, as they have different properties and roles in the body. MK-4 has a shorter half-life and is quickly metabolized, while MK-7 has a longer half-life and remains active for a longer period, supporting continuous bone and cardiovascular health. Combining both forms may provide comprehensive support for bone health and calcium metabolism.”

Here are a couple articles on this: https://naturalhealthresearch.org/vitamin-k2-and-bone-loss/
https://www.lifeextension.com/magazine/2022/3/bone-loss-vitamin-k-high-dose

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Profile picture for ccps101 @ccps101

Why oh why do many people here rush to buy and use so many supplements? Have those of you on the more supplements train considered improving your diet? Why buy and plug things like vitamin K when you can add some kale, carrot juice, collard greens, etc.? Not only improving any deficiency (BTW you can be tested for A, D, E and K deficiency) if it exists at all but also your GUT health?
I was just at my doc yesterday and she’d like me to up my calcium just a small amount but by DIET—more sardines with bones, bok choy, etc. I don’t have one doctor out of the three main ones I see for my conditions that tell me to go buy a bunch of supplements. They ALL suggest DIETARY improvements!

Sorry I just do not get the mindset here of supplements upon supplements. Especially when it has been shown over and over that diversification of diet and the gut improves OVERALL health! My two cents.

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@ccps101 I don't think there's any foods than can supply the high doses of Vitamin K in MK-4 and MK-7 forms that are recommended for osteoporosis.

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Profile picture for ccps101 @ccps101

Why oh why do many people here rush to buy and use so many supplements? Have those of you on the more supplements train considered improving your diet? Why buy and plug things like vitamin K when you can add some kale, carrot juice, collard greens, etc.? Not only improving any deficiency (BTW you can be tested for A, D, E and K deficiency) if it exists at all but also your GUT health?
I was just at my doc yesterday and she’d like me to up my calcium just a small amount but by DIET—more sardines with bones, bok choy, etc. I don’t have one doctor out of the three main ones I see for my conditions that tell me to go buy a bunch of supplements. They ALL suggest DIETARY improvements!

Sorry I just do not get the mindset here of supplements upon supplements. Especially when it has been shown over and over that diversification of diet and the gut improves OVERALL health! My two cents.

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@ccps101 Most of the people here haven't rushed. We are on this site to research, learn, and compare notes and perspectives with others, including yourself.

As one example, I have spent several months reading about Vitamin K MK4 and have looked at about 28 sources from research papers and doctor's interviews. As an outcome I am only this week starting to take only 1/3 of the Japanese protocol while continuing to research.

As a second example, @kathleen1314 has shared many research links about taking Strontium which I and others have read carefully. Some have decided to take Strontium supplements, and others (including me) to not take strontium, after reading those and considering their current person situation.

Again, I appreciate your perspective and suggestions around diet!

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Profile picture for kfhoz @kfhoz

@ccps101 Most of the people here haven't rushed. We are on this site to research, learn, and compare notes and perspectives with others, including yourself.

As one example, I have spent several months reading about Vitamin K MK4 and have looked at about 28 sources from research papers and doctor's interviews. As an outcome I am only this week starting to take only 1/3 of the Japanese protocol while continuing to research.

As a second example, @kathleen1314 has shared many research links about taking Strontium which I and others have read carefully. Some have decided to take Strontium supplements, and others (including me) to not take strontium, after reading those and considering their current person situation.

Again, I appreciate your perspective and suggestions around diet!

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@kfhoz I was in the process of pulling together some material about MK-4 for my cardiologist who specializes in cancer (mine is breast cancer). At my recent visit, I asked her if she thought it would be okay for me to take MK-4 since I am on Eliquis, one of the newer blood thinners known as DOACs (direct acting oral anticoagulants). Since I have a history of atrial fib, I have ruled out MK-7 because some people report heart palpitations. My cardiologist/oncologist said she didn't know anything about MK-4 but would pass my information on to the pharmacist affiliated with the hospital.

I am impressed by your research of so many sources! Your decision to start with 1/3 of the Japanese recommended dosage for MK-4 is exactly the one I have in mind. The following article is one that supports my decision about using a lower dose:

Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis

Key takeaway:
"In postmenopausal women with osteoporotic fractures, supplementation with either 5 or 45 mg/day of MK-4 reduces ucOC to concentrations typical of healthy, pre-menopausal women.
https://pubmed.ncbi.nlm.nih.gov/30816822/;

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Profile picture for daisy17 @daisy17

@ccps101 I don't think there's any foods than can supply the high doses of Vitamin K in MK-4 and MK-7 forms that are recommended for osteoporosis.

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@daisy17 who is doing the recommendations? Your doctor? Some study? You can be tested for DEFICIENCIES in all the fat soluble vitamins, I know because one of my conditions causes poor absorption of these so I am tested. I’m sorry but to me there are way too many people running around from supplements to more supplements looking for a miracle cure-“oh look a new study that says X” and who are NOT talking to their medical teams, who are obsessed with the next big thing for this condition. Maybe because I have multiple conditions and because I was down that road, 15 years ago one of my rare diseases several studies came out saying X supplement might be beneficial but guess what, now they are telling patients STOP taking that supplement. Sorry IMO you all are playing with fire. One of my medical teams has people bag up and bring in supplements and go through them one by one. If you are DEFICIENT your medial team can help. But all this racing around on to the next supplement and the one after that and the one after that to the point where people are supplementing the supplements seems really risky IMO. One of my specialists sees a lot of toxicity for people taking all this stuff without a total determination of their DIET is deficient. And as I said all three of my main medical team want DIET first.
I know many of you disagree, it’s also the main reason I stop on this board infrequently because to me this whole thing is playing with fire. /end rant

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Profile picture for raeb2026 @raeb2026

I find it very worrisome that folks looking for help fighting or preventing osteoporosis, are relying on AI for their decisions. That might be fine for buying a skillet at Amazon, but for planning your health needs? I don't think so. At least use bonafide medical on line resources and then review with your physician.

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@raeb2026 could not agree more. In addition to over reliance on AI, there appears to be many cites to articles written by sellers of all sorts of supplements.

Supplements are not regulated/tested and it is the Wild West out there. When looking for authority/info to make a decision, probably best to go with reliable medical sources, not 'info' provided by sellers.

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