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Polycythemia Vera: Just been diagnosed
Blood Cancers & Disorders | Last Active: 23 hours ago | Replies (484)Comment receiving replies
I was diagnosed with polycythemia Vera in February 2026. Currently on 1000mg of hydroxyurea and 81 mg aspirin daily.
I also have hypothyroidism - 20 plus years - and on 100 mcg levothyroxine daily. My TSH levels have been stable for years. Last result in September was 3.76. In prep for my annual physical I had the usual lab tests ordered last week. My TSH levels jumped to 6.86, out of normal range.
Reading up on drug interactions with HU, there doesn’t appear to be any issues with levothyroxine. I take the levothyroxine in the morning and the HU at night.
Has anyone with PV experienced problems with their thyroid?
Replies to "I was diagnosed with polycythemia Vera in February 2026. Currently on 1000mg of hydroxyurea and 81..."
@petoskeyb
Same situation as you. Taking 100 synthroid for hypothyroidism for years and normal TSH results. Started HU 500 daily last June for PV. Just had thyroid tests and TSH has doubled to 7.6 since last year's thyroid test but T3 and T4 results remain the same.
Oncologist doesn't want to address this since HU working well on blood counts. So my PCP has increased synthroid to add 1/2 pill on Sat and Sun. I don't want to keep increasing synthroid because I also have osteopenia. HU has had many more unwanted side effects so I'm adding another to my list. I might decide to see an endocrinologist.
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@petoskeyb I was diagnosed with PV 4 years ago and have been on HU (500mg) since.
Have had no issues with my Thyroid, but I do now have an enlarged Spleen.