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Help with clinical trials (RMC-6236 and it's variations)

Posted by aj @eceaj, Nov 5, 2025

Hi everyone,
My husband who has stage 4 pancreatic cancer is approaching the end of his chemotherapy treatment and i'm trying to explore next step options / trials but the information can be really confusing and overwhelming in terms of inclusion criteria.

He was diagnosed stage 3 and had a whipple. Post whipple he started on Folfrinox and then switched to Irinotecan due to tolerance issues. 2 months later a pet scan revealed mets in his liver so the chemo was considered not effective and switched to Gem/ Abraxane which he responded wonderfully to. His latest scans that all the mets have dissapeared. We have 6 more chemotherapy sessions to go.

Can he get on any versions of the RAS inhibitor trials? Or has he had too many prior lines of chemo? I'd be delighted to hear from those of you that have been on the trials or if anyone can point me in the right direction that would be great.

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marienewland | @mnewland99 | Feb 25 9:25am
In reply to @gamaryanne "I second the KRAS kickers site. I am also in a group chat with REV MED..." + (show)
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I second the KRAS kickers site. I am also in a group chat with REV MED clinical trial participants since I was one. Many people have had long lasting, stabilizing results. There is a KRAS G12D specific drug as well as one that is used against all KRAS “varieties”.
It is being tested on many Pcancer patients as well as NSCLC patients. I cannot tell from discussions which are having better results. We are being told by many sources that the pan KRAS drug, now named Doraxasonib(or similar!) will be released this year. This is why many trials are concluding. However, they are continuing some trials where it is being tested in combination with current therapies like Gemcitabine.
It stabilized and shrunk my target tumor for about 5 months then I chose to hop off it and have targeted radiation while it was small. I was in a phase 1 trial with both drugs, so the appropriate dosing had not yet been set. I am KRAS G12D, TP53, and ATM. No genetic mutations known.

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@gamaryanne
Have you had your mutations tested lately?
I did the liquid biopsy (Guardant 360) and the only mutations found were TP53 and SMAD4 (this one related to gastric cancer). My KRAS-G12D and ATM were no longer detected.

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strongone21 | @strongone21 | Mar 26 11:23pm
In reply to @ekaptur "@strongone21 Hi, my husband is participating in a clinical trial at Moffitt Cancer Center in Tampa...." + (show)
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@strongone21
Hi, my husband is participating in a clinical trial at Moffitt Cancer Center in Tampa. Accordingly, all monitoring, testing, and overall care must be conducted under the supervision of the Principal Investigator of this trial.

During the first four cycles (each cycle is 21 days long), follow-up labs are done on Day 1 and Day 15 of each cycle. Starting with Cycle 5, labs are done on the first day of each new cycle. CT scans as part of the trial are performed on average every two months.

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@ekaptur could you please share how your husband manages side effects like diarrhea and nausea with RMC-6236 for 8 months now? Was it worse in the beginning and got better? Any tips you can share will be helpful as we look at this. Thank you

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Colleen Young, Connect Director | @colleenyoung | 17 hours ago
In reply to @strongone21 "@ekaptur could you please share how your husband manages side effects like diarrhea and nausea with..." + (show)
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@ekaptur could you please share how your husband manages side effects like diarrhea and nausea with RMC-6236 for 8 months now? Was it worse in the beginning and got better? Any tips you can share will be helpful as we look at this. Thank you

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I hope @ekaptur returns to answer your questions.

@strongone21, are you taking part in the trial RMC-6236?

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strongone21 | @strongone21 | 17 hours ago
In reply to @colleenyoung "I hope @ekaptur returns to answer your questions. @strongone21, are you taking part in the trial..." + (show)
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I hope @ekaptur returns to answer your questions.

@strongone21, are you taking part in the trial RMC-6236?

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@colleenyoung Yes my husband just started.

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Elena K | @ekaptur | 2 hours ago
In reply to @strongone21 "@ekaptur could you please share how your husband manages side effects like diarrhea and nausea with..." + (show)
Profile picture for strongone21 @strongone21

@ekaptur could you please share how your husband manages side effects like diarrhea and nausea with RMC-6236 for 8 months now? Was it worse in the beginning and got better? Any tips you can share will be helpful as we look at this. Thank you

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@strongone21 Sorry for the delay in responding. Granisetron 1 mg helps well with nausea. And over time we’re able to coordinate with the doctor to take the tablets in the evening, and this has almost completely relieved the nausea symptoms. Diarrhea went away about two weeks after the start of the first cycle.
Another suggestion might be to try acupuncture to help with persistent fatigue and low energy while on the trial. Based on his oncologist’s recommendation, due to progressive neuropathy (after chemotherapy, not related to the RMC-6236 trial, and medications didn’t help), he started acupuncture and the effect has been very positive: reduced numbness in the fingers and soles, and much more energy throughout the day.

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