Help with clinical trials (RMC-6236 and it's variations)

Find a location near you that is enrolling and ask your Mayo doctor to refer you. You can find trials for KRAS G12D directly on the Revolution Medicine website. Also look on NIH website

@ekaptur Hi, can you share more in terms of expectations on where the trial related tests had to be done for your husband? For example if Mayo shares records with the trial location, can tests be done at Mayo? Also how often did you have tests during the first few months and then ongoing?

@strongone21
Hi, my husband is participating in a clinical trial at Moffitt Cancer Center in Tampa. Accordingly, all monitoring, testing, and overall care must be conducted under the supervision of the Principal Investigator of this trial.

During the first four cycles (each cycle is 21 days long), follow-up labs are done on Day 1 and Day 15 of each cycle. Starting with Cycle 5, labs are done on the first day of each new cycle. CT scans as part of the trial are performed on average every two months.

Thank you so much @ekaptur!

@strongone21
Revolution Medicines has just opened a new clinical trial (in Virginia). Take a look, this information might be useful for NSCLC: https://clinicaltrials.gov/study/NCT07397338

Thank you @ekaptur, we will look into the trial. It looks like just one location offered, but will talk to them and get more info. Thanks again!

@ekaptur we are having to travel to the trial location and likely to be 6-8 hours away. What’s the lab work done on days 1, 15 for each cycle? And is that something we can do locally and send results systematically?

@strongone21
Considering that each clinical trial has its own protocol including required tests, labs, visit schedule, etc., I think it would be best to clarify the specific requirements of the new clinical trial. My husband’s schedule, labs, and tests were determined by the protocol of the RMC-6236 clinical trial for pancreatic cancer, and they may differ significantly from the new trial for NSCLC that I mentioned earlier.
I believe that most tests are typically performed directly at the hospital where the trial is conducted. You may also want to ask whether Revolution Medicines covers lodging expenses during the testing period, sometimes they reimburse hotel costs and/or gas expenses. Considering the amount of time you may spend traveling, that could be helpful.
On average, during each trial visit, we spend about 3–5 hours at the hospital.

Thank you @ekaptur , that makes sense. It's a new unknown path we are navigating and it's been scary to think about how we can reasonably manage it especially when driving around a cancer patient for several hours and doing that often.

My experience-once into the trial the time at lab/hospital became less frequent. I believe it took about two months for that to happen. Meanwhile, we drove 3.5 hrs the night before and stayed in nearby hospital hotel. We sort of made it a get away time.