Anyone had success with Low-Dose Naltrexone for PEM, Chronic Fatigue?

@lesligirl02 Thanks for posting about how LDN is helping your fatigue. I tried it when I first became ill, and it didn’t seem to help. Your report encourages me to try it again. Hope you continue to improve.

LDN has been life-changing for my Long COVID pain: my very first 1.5-mg pill brought my score down from ~7-8.5/10 to ~3-4/10, literally overnight. I've been taking 4.5 mg for a few years now (through AgelessRx online) and would say that it has eased my CFS and PEM more gradually and subtly.

I'm currently trying lumbrokinase + bromelain + an enhanced form of NAC to clear microclots and restore oxygen delivery, which I'm hoping will help my CFS and PEM more than LDN has.

Wishing you well.

@junelightgoldberg I saw improvement at 3 mg and even more at 4.5 mg. Really improved my energy and lessened pain from the chronic inflammation. I feel better one year into LDN than I have in the 6 years of long covid!

@vostie So good to hear.

@carlosmayo what are you symptoms when on computer? For me within minutes on a computer I get very dizzy, migraine pain and blurry vision. I’ve only been on LDN a month and it’s slowly helping a little already, but I’m not ready to walk more than a block or two, and even several minutes on computer still causes issues. But given the very vivid dreams LDN is causing, I’ve been told my body is responding even at lower dosage. Hoping to get to an optimal dosage in the next month, but then wait another 3-4 months to see what the full effect will be.

@junelightgoldberg
have you any idea which filler the pharmacy used with the LDN?

@lesligirl02
I don’t know what the pharmacy used.

@onpainsufferer

Thank you for your message. About three years ago with a few minutes of computer use I used to get intense headaches and pain in my eyes (dont remember the details of the eye pain - kind of like headache but centered behind my eyes). The eye pain was part of photophobia in general - bright lights in general bothered me. With LDN and also Abilify those problems have completely gone away - I can work for hours on the computer without any problems. Similarly I used not to be able to walk around the block because of fatigue, now I can go on five mile day hikes, and shorter backpacks. I wish you the best with recovery.

@junelightgoldberg
Hi, you should call the pharmacy and ask them which filler they used when they compounded your LDN prescription.

My doctors who prescribed LDN for me; one was from Stanford Univ and the other in Chapel Hill; I found the Chapel Hill doctor because he was the specialist on the contrast dye I retained in my system, and I did a study with Standford University regarding the same thing, both of them recommended the LDN, but I had to find a pharmacy here in town to compounded it. and I knew nothing of that.
I used Medtown on Beach Blvd because, after my research on LDN and the fillers, I was able to speak with them and they were incredibly knowledgeable about LDN because they compound it.; any issues or concerns, I was able to call and talk to the pharmacist. I knew it was going to have a lactose filler; I have always had IBS, but tried it anyway and it bothered me a little, thought maybe I was lactose intolerant because had always had IBS, most of my adult life.
So I inquired about the different fillers at different pharmacies, tried 2 of them but it did not feel like it was working, and was diligent because that is what the LDN site said, all the fillers are not the same, so know your filler, so I went back to Medtown and kept the lactose filler; I feel really well when I take it and honestly I was taken by surprise by how many different issues it was resolving for me. I was keeping a list for a while because I was so surprised at how well I was felt, and by how many issues were being resolved as I went on.
I would say call the pharmacy where you filled your prescription and see which filler they used.
I hope this helps some.