Anyone had success with Low-Dose Naltrexone for PEM, Chronic Fatigue?

Two different physicians recommended LDN for me because I had retained a contrast dye in my system from a procedure in 2017, had many issues from that, and finally started chelation in 2022 once I found someone who specialized in that. Near the end of my chelations in 2024, I still had some issues; a shortness of breath, brain fog, tiring easily upon taking my normal walks, serious muscle and joint pains, etc.

I did not get covid vaccines because I was told my immune system was already compromised from the contrast dye, but I did get covid one time. Many of the covid residual issues crossed over with some that I was already having from the contrast dye.

I decided to start the LDN; they started me at 1.5 mg and went up each month by a half and I am at 3.0 right now. I stopped taking the LDN for a while because I was going to have a colonoscopy, and then started back.
The filler they used was lactose, and I decided to take it at bedtime; my experience has been really good.
The first thing I noticed was how well I felt upon waking after the first night. In a few days, I noticed my shortness of breath was no longer there, and soon following, muscle and joint aches and pains went away; and then I noticed that my sinus' seemed to be clear and I was not stuffy anymore. Things started getting better; most probably helped because LDN is an amazing anti-inflammatory for inflammation, throughout your body.

I continue to take it and went back to look at some of my blood work, just for curiousity to see if I could see anything; and I did. From July 2024, through July 2025, my creatine, eGFR, and glucose numbers had gotten either higher or lower than they should have been. At the end of July 2025, I started taking the LDN, and when I did blood work in early Sept, those sets of numbers had since gone back to the good place that they were before. in July 2024. My research said that LDN is healing to the immune system, I believe that to be true, now.

Also read that the fillers the compounding pharmacist uses when compounding your LDN prescription, matters; some fillers interfere with the efficiency of the medication, I read. The LDN has helped me immensely.

Lesligirl02, I’m so glad to hear about your dramatic improvement on LDN. 5 days ago I started at 2.5 mg after slowly going up every 2 weeks from a start at .5 mg. I don’t see any change yet but remain hopeful.

@junelightgoldberg I saw improvement at 3 mg and even more at 4.5 mg. Really improved my energy and lessened pain from the chronic inflammation. I feel better one year into LDN than I have in the 6 years of long covid!

As I posted in a LDN thread elsewhere, LDN has helped me tremendously. It along with Abilify have reduced my symptoms 75-80 percent - life changing. I used not to be able to walk around the block or use a computer. Now I can go on short backpacking trips (4 miles a day), and have unrestricted use of a computer. And I almost never crash anymore.