Does anyone have joint pain while taking xcopri?

Good Morning @shakyshake !
Welcome to our group at Mayo Clinic Connect — I hope it brings you much support throughout your epilepsy journey!
I haven't tried Xcopri myself, but having looked at its official prescribing information, joint pain does not appear among its listed side effects.
Joint pain can have many causes, including low levels of potassium, calcium, magnesium, vitamin D, or vitamin B12. Have you had these checked recently and discussed them with your doctor?
Chris

@santosha
Hi Chris,
No, I haven't had any lab work since starting xcopri. I will have to schedule an appointment with my GP. I did let my neurologist know about the pain and she reduced my dose from 150 to 100 and will have to wait to see if that helps. The pain is severe so I'm looking to see if anyone has experienced this or if it's just me. What has worked for you?
Thank you,
Alma

@shakyshake
Good Morning Alma!
I hope decreasing your Xcopri dose helps relieve the joint pain. 🙏
Thankfully, I haven't had joint pain with my current epilepsy medications — Keppra and pure CBD oil.
My neurologist and gynecologist — I'm already in perimenopause — ask me to do regular blood tests to monitor my levels of potassium, calcium, magnesium, vitamin D, vitamin B12, and others.
Could your neurologist or epileptologist do the same?
Chris

@santosha
Hello Chris,
Yes, It's better, thanks for asking. I can now move around the house although I still have to rest a lot because I have found my self getting exhausted easily. I'm taking Tylenol 500 in the morning and 500 before bed and I have increased my vitamin D3. I'm also taking zinc with magnesium and selenium, it has vitamin B6 so I'm hopping this helps until I get my blood work done.
How does CBD oil work for you? how do you use it?

@shakyshake
Hi Alma,
Lovely to hear you have been feeling better!
Initially, I was on cannabidiol alone as a replacement for my AED, alongside a trigger management approach and a treatment agreed upon between my neurologist and gynecologist to address my catamenial seizures. It helped me reduce my seizures well, and I felt much better than I had during the time I was on certain AEDs.
But then, in December 2024, high stress from the delicate health situation of both my parents caused my seizures to worsen, and my doctor had to add Keppra. I became seizure-free during the first half of 2025, though with many side effects from Keppra, even after some dose reduction. So rather than reducing my Keppra further, my doctor decided to reduce my cannabidiol instead and the seizures returned. He restored my previous dose, but they continued, so he raised it a little further. They are now better controlled, thankfully.
I hope you get your blood test done soon and that the results give your doctor some useful guidance! Please keep me updated!
Chris