Dermatitis as a Prolia Side ecfect

I got my first injection at the end of February 2023, and another one I believe at the end of August I had no reaction after the first shot and began to get red rash on my cheeks and forehead after the second shot it has diminished now and I am going to see a dermatologist who specializes in skin allergies I don’t get my neck shot until the first week of March so I’ll have the results before that

The rash appeared within the first week after receiving the injection.

I started my Prolia injection in May 2025. In December 2025 i noticed circular red dry patches that were itchy. After some process of elimination I realized the only new medication I tried was the Prolia. Has anyone experienced this type of rashy patch?

Just reading this now but want to share my experience with three medications used to treat osteoporisis. At the osteopenia stage my doctor prescribed Fosamax. I had severe diarrhea and had to stop taking it. My doctor then prescribed Prolia. After a couple injections I began getting itchy bumps, mostly on my inner thighs. Neither my regular doctor nor my dermatologist said there was any connection to Prolia. I got an Rx for Clobetasol to treat the bumps/rashes. After another injection and more bumps/rashes, I raised the possibility of a connection with both doctors and again, both said my skin issues were due to some other cause. (Why do doctors so often suggest stress as a cause?!) I expressed concern to my main doctor about getting another injection but she insisted I was at severe risk of a fracture, so I got it and boy do I regret doing that. Not only did I get more itchy bumps but my eyes itched and I had a dry cough. I relayed this to my doctor and she said, 'OK let's take you off Prolia.' Next step was to see an endocrinologist and get the green flag for Reclast.

Here I want to mention that another, and in my mind a much more serious, side effect of Prolia is that when you stop taking it, you can be at higher risk for 'rebound fractures.' And for me this happened. One day, doing something I've done hundreds of times, resulted in a compression fracture at T5/T6. I am so regretful of agreeing to take Prolia without asking more questions. I am also quite disappointed in my doctors for failing to do the work to identify the connection between Prolia and the skin problems, and for not warning me about the increased risk of fracture after stopping the medication.

Now I am on the Reclast therapy. Have had one injection. The skin issue has not gone away and in fact has worsened. I haven't found any information connecting Reclast to skin rashes. Nonetheless, after years of itching, next time I visit my doctor I will ask a lot of questions about the side effects versus lifestyle changes aimed at prevention, namely regular exercise and resistance training (which I already do) and simply being very careful. Thanks for reading and sharing any advice.

@jmora0691
I also noticied the same thing after about 4 to 5 months. Retrurned to Dr and had many other side effects including severe fatigue. She said to stop Prolia and increase Vit D and calcium and see her in 6 month. I am also very sensitive to med. Am seeing derm next month. I only had 1 prolia shot so there will be no rebound effect.
You are not alone on this. I have seasonal allergy so take antihismane which may have helped this from starting earlier, this drug also made my sinus worse.