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Is anyone taking Xcopri?

Posted by lynn0225 @lynn0225, Oct 29, 2025

My husband is on a new medication, Xcopri. I was wondering if anyone else is taking it.

He had his first seizure at the end of April 2025. He is 72 years old. The doctor who saw him at the hospital prescribed 1000 mg of Keppra twice a day. It made him very drowsy. He asked about having the dose lowered but the doctor said he couldn’t guarantee that a lower dose would keep him from having a seizure. My husband changed doctors.
The new doctor put him on Xcopri. He takes it at bedtime so he isn’t drowsy during the day.

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keeg1010 | @keeg1010 | Feb 10 4:28pm
In reply to @jemollica "@keeg1010 thank you for the information which I will discuss with. My son’s neurologist I describe..." + (show)
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@keeg1010
thank you for the information which I will discuss with. My son’s neurologist
I describe his painful electrical seizure like sensations as internal as there’s no outward jerking And shaking like he would have when he was getting his outward seizures
At most he will experience a flutter of his fingers and occasionally a tightening to his chest and then difficulty in talking
His sensations will mostly be the entire head and sometimes isolate to just an area left , right or crown
Since his anterior temporal lobectomy he has not had an outburst of external shaking , jerking seizures in about 2 years which were focal seizures

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@jemollica
I wish you and your son the best. It's terrible and extremely frustrating when you don't have answers. If you ever want to talk or need more information on Epidiolex, always feel free to reach out.
Kerry

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keeg1010 | @keeg1010 | Feb 10 4:30pm
In reply to @santosha "@keeg1010 Hi Kerry Thank you so much for jumping in to share your son's experience on..." + (show)
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@keeg1010
Hi Kerry
Thank you so much for jumping in to share your son's experience on Epidiolex with @jemollica — really appreciate you taking the time! 💜
Chris

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@santosha
Hi Chris,
Absolutely! Always feel free to tag me if you think I can help. Looking forward to talking with you soon!
Kerry

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jemollica | @jemollica | Feb 10 5:08pm
In reply to @keeg1010 "@jemollica I wish you and your son the best. It's terrible and extremely frustrating when you..." + (show)
Profile picture for keeg1010 @keeg1010

@jemollica
I wish you and your son the best. It's terrible and extremely frustrating when you don't have answers. If you ever want to talk or need more information on Epidiolex, always feel free to reach out.
Kerry

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@keeg1010 thank you

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Mentor
Chris Gautier, Volunteer Mentor | @santosha | Mar 24 9:44am
In reply to @ellierwin "Yes I take xcorpi." + (show)
Profile picture for ellierwin @ellierwin

Yes I take xcorpi.

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Hi @ellierwin
I've just caught up with your post — I was on holiday until last week, so I'm a little late to the conversation, but welcome to the Epilepsy & Seizures group at Mayo Clinic Connect!
Thank you for sharing your experience with us. How has Xcopri been working for you so far? And if you don't mind sharing — what type of epilepsy and seizures do you have?
Chris

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ellierwin | @ellierwin | Mar 24 10:17am
In reply to @santosha "Hi @ellierwin I've just caught up with your post — I was on holiday until last..." + (show)
Profile picture for Chris Gautier, Volunteer Mentor @santosha

Hi @ellierwin
I've just caught up with your post — I was on holiday until last week, so I'm a little late to the conversation, but welcome to the Epilepsy & Seizures group at Mayo Clinic Connect!
Thank you for sharing your experience with us. How has Xcopri been working for you so far? And if you don't mind sharing — what type of epilepsy and seizures do you have?
Chris

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@santosha xcorpi is working really well and I have peti mal seziures.

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Mentor
Chris Gautier, Volunteer Mentor | @santosha | Mar 24 4:18pm
In reply to @ellierwin "@santosha xcorpi is working really well and I have peti mal seziures." + (show)
Profile picture for ellierwin @ellierwin

@santosha xcorpi is working really well and I have peti mal seziures.

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Hi @ellierwin
If I'm understanding you correctly, XCopri has stopped your grand mal seizures — which is wonderful news! You mentioned you're still experiencing petit mal seizures, though. How often do they occur, and what has your doctor said about bringing those under better control?
Chris

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