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muscle weakness from blood thinners like Eliquis

Posted by twessel @twessel, Jan 29, 2025

I have been taking Eliquis for paroxysmal atrial fibrillation Recently, I have experienced muscle weakness in my arms and knees. Has anyone experienced this type of issue

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gabriig | @gabriig | 1 day ago
In reply to @mtnmarge "@twessel I hear all of you loud and clear. Went on Eliquis three - four years..." + (show)
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@twessel I hear all of you loud and clear. Went on Eliquis three - four years ago and at first no problem. Last two years are not so good. Suffer from fatigue and weakness every day now. It's very hard for me to not be able to do what I enjoyed in the past (always busy with activities such as cycling, kayaking, hiking, gardening etc. Now it's a big deal just to get dinner ready! Just recently was told I have some kind of tricuspid valve problem that is serious (so I was told). Doc said fatigue and weakness probably due to tricuspid problem. Why did it take so long to decide this may be it - after all the EKGs, scans, echos etc they are just finding this out? Anyway, I think that the Eliquis may be playing a part in this also. I want to be daring and stop the Eliquis and find out if it indeed is the root of the problem but.......almost a lose/lose proposition. Hope this makes sense. Fatigue also affects my mental state so I'm never sure if I'm doing/saying the right thing or not. Aging is hell....no cure!

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@mtnmarge On Eliquis for six months. When I mentioned side effects, was told that I'd be off it after six months and then we'd find out. What I have found out is that the side effects have continued. Hurting all over has stopped, but joints in hips, knees and shoulders are incredibly painful at initiation of first use, as getting up from a chair. Like most of those who comment, I've always been active but also hyper flexible. Wish there was research into why it affects some people and not others.

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ruth36 | @ruth36 | 8 hours ago

Yes, i’ve been on Eliquis after my heart attack in December 2024 and it’s now March 2026. I started noticing a difference in my capability of walking one month after Starting the Eliquis and it’s gotten worse. My legs feel stiff and weak. I can’t even go Grocery shopping holding onto the cart and make it through the whole store before my legs feel like they’re ready to give out. I’ve tried mentioning that to my cardiologist and she doesn’t think that Eliquis would cause side effects like that, but I have a follow up appointment with her in a few weeks and I’m going to tell her I want off of Eliquis. It’s too expensive for one thing and I am pretty sure that’s what’s causing my problems in my muscles not just my legs, but my arms.

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