Seborrheic Keratosis Help!

Posted by crystalranae @crystalranae, Feb 20, 2025

Has anyone found anything that truly works to get rid of Seborrheic keratosis? I have 100’s on my arms and legs and now they are starting on my stomach. I refuse to wear short sleeves or shorts because they are so ugly😢 They are taking over my body and I can’t find any help.

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Profile picture for patriciauk @patriciauk

@woobus yes, I have been using this for 3 weeks. It is working very well. I have about 30 SKs on my back and a couple had become so large and disfiguring I decided I must do something. In the first couple of weeks they swelled up (no pain or irritation, just as if expanding like a dry sponge in water) now they are shrinking and peeling. I have some itching and pinkness on surrounding skin but nothing I can't tolerate. The SKs are starting to lift on the edges from the normal skin and I have read how Tazarotene does this and it is expected. Tazarotene basically destablises the abnormal cells in an SK and they self destruct. I am expecting them to gradually drop like a scab and so am moisturising with an occlusive a couple of hours after the evening application to try to avoid the scabs coming off before the normal skin underneath the SKs is healed. Some of mine are very thick and a few inches wide so any scarring from the scabs pulling off too soon might be quite big.

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@patriciauk I’m so glad you are having such a good result. I actually quit for a week just to let my skin rest. Moisturizing is good. My largest SKs are now little dots and some of the smaller ones are being more stubborn
Thanks for sharing!

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I'm so glad it is working for you too. Although these things are harmless they are quite distressing to live with.

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Profile picture for itchyrich @itchyrich

Most of the treatments listed are for AKs, which all the derms I've encountered call "precancerous growths". They love to freeze them off and charge Medicare a ton of money. Most of mine over the years have looked like dry patches of skin. While researching the treatments listed, I came across this excerpt from PubMed that I have never heard of previously. Seems interesting and I will do more research on it

"Seborrheic keratosis (SK) is a benign, common disease affecting mostly the middle aged and elderly population. SK lesions are characterized by pigmented skin growth, a warty surface, and sharp margins. Current therapies (curettage or cryotherapy) are invasive and painful. A non-invasive treatment is evaluated in this clinical study. Objectives: To assess the efficacy, safety, and tolerability of Nitrizinc Complex® topical solution (NZCS) for treatment of SK, after one to two topical applications. Thirty-two SK patients with a total of 59 lesions were treated with NZCS. Outcomes were determined by the dermatologist at clinical visits at one, three, six, and 12 months post-procedure and by subjective evaluation of patients through questionnaires. Six months after treatment, complete elimination was observed in 80% of the lesions (72% of the patients), while 93.3% of the lesions showed at least 50% reduction. Treatment ended with 100% cosmetic benefit as no scars or dyschromia were observed in the treated areas. Subjective treatment and cosmetic satisfaction were evaluated and corresponded to 8.66/10 and 8.07/10, respectively. The product was preferred over all other options previously used by all patients. Treatment was highly tolerable as discomfort, such as pain and itching/burning sensations, was minimal. No relapse cases have been observed at 12 months after treatment. This study demonstrates that NZCS is an efficient, easy-to-apply, safe and well tolerated treatment for SK lesions, and may therefore be considered as a potential topical non-invasive alternative for SK treatment."

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@itchyrich thanks for this advice, I will try it. Is the nitrizinc complex an OTC or do I need a prescription? I have tried tazarotene cream and it works but is very uncomfortable and must be used twice a day for three months. I did my front for 3 months and then had my spouse do my back…after a few weeks my skin became hypersensitive. I got friction burns in places that were not being treated!
Best, Becky

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Profile picture for woobus @woobus

@itchyrich thanks for this advice, I will try it. Is the nitrizinc complex an OTC or do I need a prescription? I have tried tazarotene cream and it works but is very uncomfortable and must be used twice a day for three months. I did my front for 3 months and then had my spouse do my back…after a few weeks my skin became hypersensitive. I got friction burns in places that were not being treated!
Best, Becky

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@woobus It's been a year since I posted that comment. At that time, I couldn't find much of anything on SKs. Today, there is quite a lot that comes up in my searches, but I still can't find anything that is exactly the Nitrizinc Complex. Sounds like it is a product, but it never comes up as one. While I have found a lot of other possible remedies, especially on Reddit for wart medicines, I have pretty much given up as I am getting too old to worry about the cosmetic aspects anymore. I also have Grover's Disease, which itches even more than the SKs, so i just keep using Eucerin Itch Relief which sort of relieves it a bit. Good luck, I hope you find something that works.

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