Any experiences with Gemcitabine + Abraxane as second line treatment?

My cancer was discovered in October 2023, I had Whipple surgery in November and went on Folfirnox, the frequency reduced in a year. In May 2025 cancer appeared in my liver and I went on Gemcitabine Abraxane in July 2025, 2 weeks on one week off, with scans every 3 months. In November there was no apparent cancer found. I am now on every other week, with three scans showing no cancer. I do rest a bit in the days just after the treatment, but still can be active, and am strong in the second week (84 years old and still working hard in the garden, and doing the usual household work). I have the option of cutting back the treatments but don’t want to take chances with pancreatic cancer at this stage; the doctor agreed.

In my own experience, I was not considered resectable, so surgery was not an option for me. I had no choice but to proceed with chemotherapy. While that path was not what I initially hoped for, it taught me that treatment journeys can still be meaningful, manageable, and worthwhile—even when they differ from our original expectations. I want to make this clear I would have had surgery if I could have. I was in a type 2 trial of the triplet ( Gemcitabine (Gemzar) with nab-Paclitaxel (Abraxane) and Cisplatin (Platinol)** along with vitamin D after that I had 33 days of radio therapy. The side effects are fatigue, nausea, diarrhea, neuropathy (tingling/numbness in hands/feet), low blood counts (white cells, platelets, red cells), appetite loss, and skin issues** I have been on 5FU as maintenance since then every 12 days for 46 hours which requires me to take home a pump. I have lived like this for 7 years

Regarding your question on experiences with Abraxane/Gemcitabine.
I've now been on it for 29 cycles (two-week cycle) or 58 treatments (over two-years). I've been able to tolerate it reasonably well, being treated at Mayo Rochester. I'm down to a 67/80% of the maximum dose and it's been effective at that level. Here are my noticeable side effects:
- fatigue and lethargy for approx. 2-3 days after treatment
- some slight nausea for a couple of days. Barely need to treat it but use Zofran when necessary.
- loss of taste starting about day 2 after treatment and running to about day 5
- significant hair loss
- neuropathy - this is the worst side effect and it's progressive. After all these treatments feet are now numb and feeling some slight numbness in fingertips. Icing hands and feet during the Abraxane infusion allegedly mitigates it and I've done it religiously.
Everyone is different and so that's where the medical "art" comes in.
Good luck.