Sibo treatment Rifaxamin and Neomycin

Posted by azj @azj, Oct 1, 2022

I have been diagnosed with SIBO and am being advised to take Rifaxamin 3x a day and Neomycin 2x a day for 14 days. I have many concerns about the Neomycin due to the ototoxicity. I have a bit of tinnitus already the think that may make me more vulnerable to a possible problem. The idea of taking something that might hurt my hearing even more is concerning. Any thoughts about the Neomycin in this context? I would like to hear about the research and if genetics can be determined to see if this would be safe for me to take.
Also, does anyone have any recommendations for a Dr. at Mayo/ Scottsdale who treats SIBO? I would like to coordinate care with my other doctors at Mayo as I think this is going to be essential to getting a handle on this.
Much gratitude in advance for this supportive community.
Take care,
Jaki

Interested in more discussions like this? Go to the Digestive Health Support Group.

Profile picture for eileen57 @eileen57

Following Breath testing, I was DX with Methane levels double the normal. Started Rifaxamin 8 days ago with a strict dietary plan. It is working somewhat but not as well as my doctor expected. Yesterday together with caution we added Neomycin 500mg twice a day. You must radically alter your diet to get success and be vigilant about the change. It's tough to do because of flimsy US food labeling. So you must do as much home cooking of fresh food as possible!! I can't say that enough. I'm having much better results only this way. I'll be happy to share my diet success with anyone out there. It is complicated but it works and it takes individual allergies, sensitivities into consideration because everyone's chemistry is different. It's helpful to monitor what you are eating at every meal so I use the free online app My Fitness Pal, recommended by my dietician. The app is easy to use, allows you to set personal goals for weight, water intake, exercise, and each element of food intake (calories, carbs, protein, fat, sugar, fiber, sodium). It's become my guide for this strict diet change for SIBO treatment. I'm not there yet, so it's a work in progress, but I am more hopeful than I was before. I've been dealing with this chronic life-changing disease since 2019, lost 20+ pounds that year, can't get my weight up to 100lbs yet, but the research is starting to improve and there is new info to help us each year. In the past 3 months, I've endured 5 different GI tests that have finally determined my underlying problem- SIBO! For years I was told I had IBS-C and IBS-D mix. That was false due to a lack of medical knowledge. Now the medical community is indicating that SIBO is underdiagnosed. Hang in there. Happy to share my successes and challenges if you ask.

Jump to this post

@eileen57 - I wanted to let you know I moved your post here to this existing discussion where the original poster, @azj, also was talking about the same medications for SIBO:

- Sibo treatment Rifaxamin and Neomycin https://connect.mayoclinic.org/discussion/sibo-treatment-rifaxamin-and-neomycin/

You also mentioned something about flimsy US food labeling. I think perhaps you are talking about something like what is described in this National Science Foundation 2025 article https://www.nsf.org/news/americans-demand-greater-clarity-standardization-food-labeling. However, will you talk more about any concerns you have with food labeling and how that affects you as a patient with SIBO?

REPLY
Profile picture for gboi @gboi

I took neomycin 2/day for 28 days and it is what finally removed my SIBO after fighting it for over 2.5 years. I would do it again in a heartbeat given how bad my quality of life was. No kidney or hearing damage, but of course your experience could always be different. I would ask your doctor/pharmacist for clarification on what the documented rate of hearing/kidney damage is, what steps you should take to minimize it, and what extenuating factors increase or decrease your chances. Only then are you in a position to make "informed consent".

Jump to this post

@gboi that is incredible and thank you for sharing. Would you mind sharing if you were able to return to a normal diet, or how you managed the sibo afterwards?

REPLY

I had tinnitus before treatment. I took both antibiotics and lasted 5 days due to stomach upset. That was a couple months ago. Same diagnosis as yours. You may tolerate it better. I don’t think my tinnitus is any worse. What symptoms do you have or had that led to the breath test?

REPLY
Profile picture for eileen57 @eileen57

Following Breath testing, I was DX with Methane levels double the normal. Started Rifaxamin 8 days ago with a strict dietary plan. It is working somewhat but not as well as my doctor expected. Yesterday together with caution we added Neomycin 500mg twice a day. You must radically alter your diet to get success and be vigilant about the change. It's tough to do because of flimsy US food labeling. So you must do as much home cooking of fresh food as possible!! I can't say that enough. I'm having much better results only this way. I'll be happy to share my diet success with anyone out there. It is complicated but it works and it takes individual allergies, sensitivities into consideration because everyone's chemistry is different. It's helpful to monitor what you are eating at every meal so I use the free online app My Fitness Pal, recommended by my dietician. The app is easy to use, allows you to set personal goals for weight, water intake, exercise, and each element of food intake (calories, carbs, protein, fat, sugar, fiber, sodium). It's become my guide for this strict diet change for SIBO treatment. I'm not there yet, so it's a work in progress, but I am more hopeful than I was before. I've been dealing with this chronic life-changing disease since 2019, lost 20+ pounds that year, can't get my weight up to 100lbs yet, but the research is starting to improve and there is new info to help us each year. In the past 3 months, I've endured 5 different GI tests that have finally determined my underlying problem- SIBO! For years I was told I had IBS-C and IBS-D mix. That was false due to a lack of medical knowledge. Now the medical community is indicating that SIBO is underdiagnosed. Hang in there. Happy to share my successes and challenges if you ask.

Jump to this post

@eileen57 best of luck to you. I took both meds for 5 days and stopped. My stomach was too upset. Everyone is different. I have IBS too. I took a blood test through IBS SMART and it was positive. Meaning I have IBS due to an infection at some point. I’ve had IBS all my life so I don’t know what and when. What were your SIBO symptoms? Hope you’re feeling better.

REPLY
Profile picture for katnewton @katnewton

I had tinnitus before treatment. I took both antibiotics and lasted 5 days due to stomach upset. That was a couple months ago. Same diagnosis as yours. You may tolerate it better. I don’t think my tinnitus is any worse. What symptoms do you have or had that led to the breath test?

Jump to this post

@katnewton
I had nausea, fatigue and constipation. I just restarted Rifaximin and will take with the antimicrobial Allicin 450 mg. I hope to be able to get up to 450 3 times a day. I will start with once daily to see how I can tolerate it. My breath test revealed both hydrogen and methane. I so hope this treats my symptoms. I pray you find relief, as well

REPLY
Profile picture for agb461 @agb461

@katnewton
I had nausea, fatigue and constipation. I just restarted Rifaximin and will take with the antimicrobial Allicin 450 mg. I hope to be able to get up to 450 3 times a day. I will start with once daily to see how I can tolerate it. My breath test revealed both hydrogen and methane. I so hope this treats my symptoms. I pray you find relief, as well

Jump to this post

@agb461 best of luck to you. I hope this combo works. I feel the natural supplements are a great plan with the Rifaximin. For nausea I use Gas X because the gas seemed to be causing my nausea. You might consider that if you have nausea. Also there’s wrist bands for nausea on Amazon.

REPLY
Profile picture for katnewton @katnewton

@agb461 best of luck to you. I hope this combo works. I feel the natural supplements are a great plan with the Rifaximin. For nausea I use Gas X because the gas seemed to be causing my nausea. You might consider that if you have nausea. Also there’s wrist bands for nausea on Amazon.

Jump to this post

@katnewton
Thanks so much for the suggestions. I will definitely try gas x, as the nausea is the worst part. Leads to feeling so depressed. It’s good to know I’m not alone

REPLY
Profile picture for marcconley @marcconley

Going to start SIBO antibiotic protocol with rifaximin and neomycin. Has anyone gone thru this and what are the effects/side effects.

Thanks.

Jump to this post

@marcconley I'm currently taking rifaximin and neomycin for IMO. I'm having several days of watery diarrhea during the last half of the 14 day course of treatment.

I don't know if this is normal or not. I seem to have a dud for a gastroenterologist.

REPLY

I went through multiple Rifaxin/Neomycin treatments and at first they seem to help but then the problem is back. After researching and talking to a couple doctors plus dietitian I realized the Archaea in my small intestine was a symptom, not the problem (IMO). I started taking antomicrobials (Atrantil, emulsified oregano oil, neem oil and alicin to fight the archaea. I took some gut health drugs and some to help my motility (Ginger, artichoke/ginger, iberogast). Look-up MMC (natural cycle in your body that has to do with timing). Remember, different people have different triggers/problems, not a single problem for everyone. Suggestions other than the alternate solution to antibiotics include: 1- Water, hydration (I do 64 oz /day), 2- Chew food very well, helps digestion, 3- Three meals / day with no snacking, keeping the time separation 4-5 hours between meals, nothing in-between having calories as that upsets the MMC. 12 hours between meals fasting ie. 6PM to 6 AM allows the body to clear out the system. 4- No antacids (stomach acid is part of the operation of your system) and when your motility gets rights you should not need them. 5- Follow a low FODMAP diet while you fight this problem.
I had the SIBO / IMO problem for a few years. Once I started on this, it took about 4 months and now I’m low gas, no pain and a regular BM schedule. I found that my body is low in producing some enzymes and now, I take no supplements other than enzymes es to have normal digestion. Good luck! - Chatbots were very helpful for me but remember that they are helpful but not always right. (Suggestion: Cross check a second BOT).

REPLY

Everyone is different and awesome enzyme production for you started some.

REPLY
Please sign in or register to post a reply.