Reclast side effects 🙁

Posted by catv @catv, Sep 25, 2025

I had terrible side effects from a Reclast infusion of 5mg.
I’m scheduled for my yearly check up with my doctor in December. I do not want to take Reclast again.
Is there anything else out there that does NOT have the same ingredients as Reclast?

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Profile picture for amdf @amdf

@roxanne1950 My first infusion was 5 years ago. I actually had a light rash that came out about 2-3 weeks later. Wasn't itchy. Did get the second infusion following year, no rash. I had other side effects, first year the worst(fatigue , little dizzy, very constipated) for about 4 weeks. each successive infusion, symptoms lessened greatly, maybe lasting 2 weeks then one week and 3-4 days for the 4th infusion. I knew to be aware of added intake of fiber and water for the constipation. My Endo told me SE's decrease with each successive infusion. (Anyway, I'm now on Forteo generic because my spine worsened. Side effects of that is another story, but I've hung in there with the worst of those lessening and some persisting. April makes 1 year. )

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@amdf
Thank you for your response. I actually developed a rash after a few weeks of the itchiness. Dermatologist was able to take a biopsy of the rash to see if it was an allergic reaction to something. Actually turned out to be something called Grover's disease - a benign condition that can come and go which causes rash/itching. so I guess not related to the Reclast after all.
I so appreciate your response.

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Profile picture for njhornung @normahorn

This study is very enlightening as they followed a single dose of ReClast for 10 years. It sure seems tome that yearly may be a gross overkill,

They also looked at 1, 2.5 and 5 mg doses.

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@normahorn, I am not seeing a date on this study. Do you know it? I would like to send this to my doctor.

Also, I note that it was done on women with osteopenia; is there any similar study with women who have severe osteoporosis (or are at least osteoporotic)?

Thanks for any help you can give. I have to decide whether to take my 2nd Prolia shot or to ditch Prolia and go to Reclast. I only took the Prolia because I had already finished my two years on Tymlos and have severe enough OP that I needed to be on a med (I am 74, frail, have several chronic illnesses and cannot entirely exercise and eat in a manner that would help my bones enough). Evenity wasn't an option because I have heart disease.

One of my docs would like to see me off the Prolia so I don't get stuck on it for life and he suggested going to Reclast. But I'm as afraid of the Reclast side effects as I am of the prospect of never being able to get off Prolia. But in reading about the long-term side effects of Reclast, I don't know that that switching is a good idea. So I'm very interested in finding out more about the lower-dose infusions and differing infusion schedules, which might help me where side effects are concerned.

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Profile picture for bayhorse @bayhorse

@normahorn, I am not seeing a date on this study. Do you know it? I would like to send this to my doctor.

Also, I note that it was done on women with osteopenia; is there any similar study with women who have severe osteoporosis (or are at least osteoporotic)?

Thanks for any help you can give. I have to decide whether to take my 2nd Prolia shot or to ditch Prolia and go to Reclast. I only took the Prolia because I had already finished my two years on Tymlos and have severe enough OP that I needed to be on a med (I am 74, frail, have several chronic illnesses and cannot entirely exercise and eat in a manner that would help my bones enough). Evenity wasn't an option because I have heart disease.

One of my docs would like to see me off the Prolia so I don't get stuck on it for life and he suggested going to Reclast. But I'm as afraid of the Reclast side effects as I am of the prospect of never being able to get off Prolia. But in reading about the long-term side effects of Reclast, I don't know that that switching is a good idea. So I'm very interested in finding out more about the lower-dose infusions and differing infusion schedules, which might help me where side effects are concerned.

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@bayhorse I googled "ten year reclast study" and several websites came up. I also found this Youtube video by Dr Lucas discussing results of a 10-year study. https://www.youtube.com/watch

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Profile picture for bayhorse @bayhorse

@normahorn, I am not seeing a date on this study. Do you know it? I would like to send this to my doctor.

Also, I note that it was done on women with osteopenia; is there any similar study with women who have severe osteoporosis (or are at least osteoporotic)?

Thanks for any help you can give. I have to decide whether to take my 2nd Prolia shot or to ditch Prolia and go to Reclast. I only took the Prolia because I had already finished my two years on Tymlos and have severe enough OP that I needed to be on a med (I am 74, frail, have several chronic illnesses and cannot entirely exercise and eat in a manner that would help my bones enough). Evenity wasn't an option because I have heart disease.

One of my docs would like to see me off the Prolia so I don't get stuck on it for life and he suggested going to Reclast. But I'm as afraid of the Reclast side effects as I am of the prospect of never being able to get off Prolia. But in reading about the long-term side effects of Reclast, I don't know that that switching is a good idea. So I'm very interested in finding out more about the lower-dose infusions and differing infusion schedules, which might help me where side effects are concerned.

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@bayhorse Bottom of first page says:

Received in original form May 12, 2021; revised form September 13, 2021; accepted September 26, 2021.
...
Journal of Bone and Mineral Research, Vol. 37, No. 1, January 2022, pp 3–11.

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