@zmg Yes! Rosacea upsets for me, too. I am 71 and on HU x 8 years. My dermatologist said no connection that he knows of, but ET causes excess histamine production, and histamines are a component in rosacea. In addition, hydroxyurea dries skin. I got mine to calm down by avoiding all scented skin products, regular moisturizing, avoiding heat/sun exposure, and taking minocycline twice a day for a couple months. I am not sure the Metrogel really does much, but I still use it.