Anyone had success with Low-Dose Naltrexone for PEM, Chronic Fatigue?

To Caldiana13
Amen to that.
June

Hi, I have been taking LDN for several years for Fibromyalgia. I had a lot of side effects ( conjunctivitis, nausea) I really did not think it was going to help me then the clouds parted and my pain was greatly diminished!. Stick with it for at least a month even if you have side effects-it worked for me-hope it will help you too .

lpool39xops, I’m glad to hear it ended up helping you a lot. From what I’ve read, it can take some people 9 - 12 months on the highest dose of 4.5 or 5 mg before feeling noticeably better.
June

I have been on LDN for 4 years. It has helped, it hasn't brought me back to the Wonder Women I was before Covid. But I have alot of symptoms other than chronic fatigue.

Went I had to request a refill from my PCP, I found out how much it helps when I had to do without until he understood how to prescribe to Mayo pharmacy.

I hope you find some relief. Just remember, nothing is a miracle drug that will make you feel like you did before Covid. You may need to find relief to your other symptoms for that.

Took 4.5 mg x 2 years. In my experience, it did not shift the PEM. Somehow I felt more blood flow to my brain; a positive feeling. Currently I'm on a medication holiday because of increased neuropathic pain that was new for me. It seems that sort of pain is less off the drug. Waiting to see neurologist for perhaps lower dose or higher? Best wishes. I think it helps many people.

@earthangel ,
Thanks for the encouragement that LDN has helped. I’m sorry you are dealing with many Long Covid issues and hope something is soon found that helps. I have been lucky that PEM is my only real issue, except a tiredly specific kind of brain fog that only deals with calendar issues and comes and goes.

Thanks for the encouragement that it has helped you somewhat . I’m sorry you are dealing with so many difficult issues and ai hope something is found soon that helps. I am grateful and lucky that PEM is my only issue besides a weirdly specific sort of brain fog that comes and goes and is limited to calendar issues.

@mayo4g
Thanks for the positive report on LDN. I hope you get help with the neuropathic pain. When my late husband began feeling severe neuropathic pain, a doctor at Memorial Sloan Kettering cancer hospital prescribed Methadone, which eliminated the pain within a week or so, I think.