Has anyone used the oral medication for dry mouth (Sjogren's)?

I use xylimelts disc for dry mouth...works very well..you can find them by the toothpaste and mouthwash..hope it helps you

My doctor put me on Cevimeline and it has helped quite a bit. Lately it feels a little drier than it's been but it could be related to allergies. I hope you find something that works for you!

Thanks. I will try.

Thanks. I will ask my doc about it.

I started pilocarpine tablets 5g three a day about a month ago. Going to keep taking it a couple more months, but so far, I don't really see any difference or improvement at all. Right now, I'm on Vevye for dry eyes and also am using blood serum eyedrops. That is helping somewhat.

But the worst of all my Sjogren's (which, after complaining about to doctors for 12 years, FINALLY got diagnosed!) is the dry dry dry nasal passages/sinuses. Man! So dry that the normal mucus just stays up there in clumps making it hard to breathe -- especially when I'm trying to sleep. 🙁

An ENT a few years ago prescribed mupirocin ointment. In a strange way. He said to squirt about a third of the tube into a bottle of saline solution that you buy at the store and shake it up. Then squirt it up my nose at least once a day. AND IT WORKED! However, I learned later (this was during the pandemic, so we were on our own a lot ... it seemed) that it's not supposed to be used forever, and I had used it for FOUR YEARS! I didn't know and the ENT didn't say anything about how long to use it. Oh, well. But when I stopped, all the problems with my nasal stuff came right back.

I really don't know what to do. I'm miserable. I started using a humidifier in my bedroom at night and will continue at least through the winter months. I also use Xlear sinus spray, which is nice, but doesn't last long.

I have taken pilocarpine for about 7 years and it works great for dry mouth, not much help for dry eyes!!

Pilocarpine seems to be working most of the day for me. I just started it 2 weeks ago. I haven’t been diagnosed yet for Sjoren’s because the bloodwork doesn’t show it. It does show ANA positive and high Centromere, but that’s for the Raynaud’s syndrome I have. I have had unbearable dry mouth since November, 2025 and tried everything. I do have a Rheumatologist because of my Osteoperosis treatment, the ANA positive with Centromere. I was told that it could be a false negative for Sjogren’s right now, but may show up later on.

I was prescribed Pilocarpine but the worst part was I got the cold sweats every time I took it. Not sure how much it helped me but the side effects were pretty rotten.

@justrosie Its so frustrating isn't it? Thanks for your story. I will mention something that worked for my dry eyes. My eye doc put in some "punctual plugs." Best thing is to Google it to explain it. A very simple procedure. I still have dry eyes, but has improved immensely since the plugs.
The mouth is a whole nothing story. I wake up so congested (throat mucus) from the severely dry mouth in the night. Probably worse than the Sahara desert. I am hoping medication might help. I want to get as much feedback if possible to see if it is worth it.

@kellen I have heard that Sjogren's it hard to diagnose. My dry mouth is also unbearable! I did hear that taking Pilocarpine could cause sweats. I hate taking anything...especially if there are nasty side effects. If it improve my dry eyes, I might take it. I feel desperate. It has gotten worse every year.