Anyone had success with Low-Dose Naltrexone for PEM, Chronic Fatigue?

I am 4 years into PVS "POST VACCINATION SYNDROME " In the life threatening PVS I cannot function . Not just pain and fatigue but extreme anxiety accompanied by extreme paranoia.
When I awoke one morning (after a chemically induced night's sleep) the brain fog gone like waking up from a monstrous nightmare. It may last a few days or months but it is without question PVS.
I am now 3 weeks out of PVS. With the help of my primary physician I changed my diet (high protein drinks and foods, lot's of sleep and minimal stress). Supplements will help but I needed to change my lifestyle.
Wish me luck
Harold goldberg
AKA: mishabear

I posted a few weeks ago about my experience with naltrexone. The Long Covid clinic that has been treating me for almost a year suggested that I try naltrexone this last autumn. I gave it 3 to 4 months and it did not do much for me. I had heard that it had helped others, but unfortunately not me. I was directed to a scientific paper out of Europe regarding the use of L-Arginine. For me, this has been a tremendous help. I have so much more energy. One of my doctors suggested I break up the daily dosage into three dosages per day. I will go back to the source and find the reference for the paper and post it later today, in case anyone’s interested. I know we are all on this journey and some things help some patients and some protocols help others. I think we all have to find our own way in this Covid fog. Wishing all my fellow travelers the best-

To Caldiana13, thank you for sharing your experiences with both LDN and L-Arginine. Since I’m in the earliest stafes of taking LDN, I’ll make a note of L-Arginine if LDN doesn’t help with 9 months.

@erinhastedt

I was told by my LC clinic that I would be ill forever - no cure for LC, and that therefore I would have to take the meds forever. It has no been five years.

As I posted in a LDN thread elsewhere, LDN has helped me tremendously. It along with Abilify have reduced my symptoms 75-80 percent - life changing. I used not to be able to walk around the block or use a computer. Now I can go on short backpacking trips (4 miles a day), and have unrestricted use of a computer. And I almost never crash anymore.

Carlosmayo, I’m glad you are SO much better . You’re giving me hope.

@junelightgoldberg

So glad to hear. Find a good long covid clinic and experiment with the different drugs they can offer you. I wish you the very best.
Carlos

@carlosmayo
I'm glad you're doing so much better, but I think the clinic that said since there is no "cure" it means you would be taking the meds "forever" are seriously out of line.
They have no way of knowing that, and for many people the symptoms will eventually lift.
That was my experience, for example, some forty years ago with Chronic Fatigue Syndrome, which felt the same as my present (1-1/2 year) bout with LC, and went away of its own accord after two years.

As far as this thread goes, and this has already been previously discussed multiple times--use the handy search tool, folks--I did try the LDN starting at a .5mg dose, going up to ten times that over a couple of months, and felt no effect for my ongoing fatigue/PEM.

@sandguy
LDn pulls some major levers with the immune system in the body, when LDN works it is amazing, but how each person's body reacts is obviously very individual.

I cannot say that LDN helped me that much either. Still, I see research and first hand reports of how much it has helped others.

A few days ago, I posted about a European study regarding L- Arginine that found that this amino acid coupled with Vit. C helped with fatigue in those with long Covid. The reference is as follows:
Izzo et al, Pharmacol. Res., Vol. 183 (2022) 106360

I hope this can help someone else. Sometimes it feels like we are all traveling this path together. Some of us are further along and some of us are just starting this struggle. However, when we can take the time to help one another, I think there is a special grace in this. May we all find our way back to good health!