I am going to start Alpha Lipoic Acid @600 mg/d to determine...

Posted by pontedeleon @pontedeleon, Feb 6, 2025

if it is effective to address pain in feet from peripheral neuropathy. Should I expect to see a drop in levels of B-12 in serum? Should I begin supplementation now of B-12? What is consensus on this?

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Profile picture for blowerk1216 @blowerk1216

@bevthenurse are you using methylated B12?

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@blowerk1216 NO! This is what I am taking, this is by injections: Cyanocobalamin 1,000 Mcg/ml Vl Generic for Cobal, Cyanoject, Vitamin B-12

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Profile picture for dieterreuther @dieterreuther

During my research of what to take for my polyneuropathy I learned from Dr Emily Splichal’s book Barefoot Strong that it has to be R-ALA instead of regular ALA: “Touted as one of the most powerful anti-oxidants, alpha lipoic acid has been shown to improve microcirculation to peripheral nerves while decreasing oxidative stress. A key point about alpha lipoic acid is that it must be taken in the R-lipoic acid form as the “R” form is the one that is biologically active (vs. “S” form).”

Initially I took it mornings and evening, but to be supportive of my silent reflux I now take the whole dosage in the morning.

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@dieterreuther for those folks taking ALA have you checked that what you are using is the R-form which is the reactive form.

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Profile picture for dieterreuther @dieterreuther

During my research of what to take for my polyneuropathy I learned from Dr Emily Splichal’s book Barefoot Strong that it has to be R-ALA instead of regular ALA: “Touted as one of the most powerful anti-oxidants, alpha lipoic acid has been shown to improve microcirculation to peripheral nerves while decreasing oxidative stress. A key point about alpha lipoic acid is that it must be taken in the R-lipoic acid form as the “R” form is the one that is biologically active (vs. “S” form).”

Initially I took it mornings and evening, but to be supportive of my silent reflux I now take the whole dosage in the morning.

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@dieterreuther that’s absolutely correct and anyone talking ALA must determine what form they are using

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Profile picture for bevthenurse @bevthenurse

@blowerk1216 NO! This is what I am taking, this is by injections: Cyanocobalamin 1,000 Mcg/ml Vl Generic for Cobal, Cyanoject, Vitamin B-12

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@bevthenurse are you using methylated B12?

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Profile picture for mrmacabre @mrmacabre

I've been taking 1200mg a day for over a year, and it has made a difference in my pain. A small difference, but I'll take any help I can get.

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@mrmacabre how long did it take to have an effect?

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Profile picture for blowerk1216 @blowerk1216

@mrmacabre how long did it take to have an effect?

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@blowerk1216 I have not taken the orally B12. I also take B Complex 50 and have for many years, it didn't do much for the neuropathy. Since I started the IM monthly injection of the B12 3-4 months ago by my primary Dr , I have gradually noticed less pain. In fact they are feeling much better. Her office is in my building and she comes to my apartment. I started Tuesday with getting the every week injections, my son-in-law gives it to me. I also soak my feet for 20 minutes with Epson Salts in the water every day or so and get a foot massage afterwards. I massage my feet before I go to bed at night. I have tried several different creams for the massage's and have found that these 2 are the best: WISE-MEN healing balm massage for my after the foot soak soaks and I massage with Hempvana #1 Ultra Strength with Lidocaine and Hemp before I go to bed and put my fuzzy sleeper socks on. I try to keep my feet elevated as much as possible. I don't believe my neuropathy is as bad as some people have. I am not a diabetic. Best to you, Beverly

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Profile picture for bevthenurse @bevthenurse

@blowerk1216 I have not taken the orally B12. I also take B Complex 50 and have for many years, it didn't do much for the neuropathy. Since I started the IM monthly injection of the B12 3-4 months ago by my primary Dr , I have gradually noticed less pain. In fact they are feeling much better. Her office is in my building and she comes to my apartment. I started Tuesday with getting the every week injections, my son-in-law gives it to me. I also soak my feet for 20 minutes with Epson Salts in the water every day or so and get a foot massage afterwards. I massage my feet before I go to bed at night. I have tried several different creams for the massage's and have found that these 2 are the best: WISE-MEN healing balm massage for my after the foot soak soaks and I massage with Hempvana #1 Ultra Strength with Lidocaine and Hemp before I go to bed and put my fuzzy sleeper socks on. I try to keep my feet elevated as much as possible. I don't believe my neuropathy is as bad as some people have. I am not a diabetic. Best to you, Beverly

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@bevthenurse thank you

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Profile picture for blowerk1216 @blowerk1216

@blowerk1216 have you checked that this is methylated B12 that you are taking?

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Profile picture for blowerk1216 @blowerk1216

@mrmacabre how long did it take to have an effect?

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@blowerk1216 I'd have to say a couple of weeks maybe, it's been a while now since I started taking it. All I know is that my really bad night time flare ups haven't happened since I first started. The only reason I'd even heard of this supplement was because my doctor recommended I try taking 1200mg a day.

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Profile picture for blowerk1216 @blowerk1216

@dieterreuther that’s absolutely correct and anyone talking ALA must determine what form they are using

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@blowerk1216 Where do you get your R Ala?
What brand? Link or photo please 🙏

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