Central Sensitization Syndrome (CSS) treatment approach: Function is the key!

Aug 27, 2025 | Tanya Crowder, OTR/L | @tanyaot | Comments (27)

We explored CSS in a previous post. Let's take a deeper look at its impact.

People with chronic pain and other chronic symptoms may have a central nervous system that has become sensitized over time.  Central Sensitization Syndrome (CSS) can be described as a louder message from the body to a more sensitive receiver in the brain. When you have sensitization, your body overreacts to sensory signals as if they are dangerous. This can result in worsening of symptoms such as pain, fatigue, nausea or other movement related challenges.  The long-term consequences of this upregulated system can include:

  • Physical deconditioning
  • Emotional distress
  • Increased reliance on medications to feel better
  • Increased frequency of treatments or interventions
  • Decreased functioning
  • Decreased quality of life

What is the best approach to address these consequences?

Unfortunately, there is no way to turn back the clock and “un-sensitize” your nervous system. Patients are often left feeling frustrated by the lack of effective treatments.

In the Mayo Clinic Pain Rehabilitation Center (PRC) program, patients learn lifestyle management, stress management and physical re-conditioning strategies to improve their ability to effectively engage in their daily activities.  This approach enables patients to not only improve their functioning, but in time can also lead to improvement in symptoms as well.

Some examples of functional improvement for our PRC graduates:

  • Travel: local and international
  • Vocation: Work, school or volunteering
  • Family life and caregiving
  • Leisure and recreational activities: crafts, reading, kayaking, hiking
  • Community involvement and social activities

Patient outcomes also include improved mood, decreased anxiety, decreased interference from symptoms and a better perception of health.

Getting back to life is the goal and focus on function is an effective tool.

Authors: Kyle Bovee DPT, Tanya Crowder OTR/L and Elke Lacayo OTR/L

 

Interested in more newsfeed posts like this? Go to the Chronic Pain & Symptoms Rehabilitation blog.

Profile picture for mathqueen @mathqueen

Thanks for sharing your story. Do you still take the benzo or have you recovered?
Best
Masha

Jump to this post

@mathqueen regrettably my pain went to my central nervous system and im diagnosed with CRPS which tends to worsen over time. Yes i probably have built a slight tolerance but more i think the level of pain is so much worse its really hard for a benzo to eradicate it but it def helps greatly. No doubt im on it for life unless the pain magically disappears.
I really find meditating, sitting in nature ( on good days) does help calm nervous system tremendously and of course pain all comes from the brain, so trying to retrain the brain away from pain is important. About 2 months ago I seriously started following Joe Dispenza and understanding all the scientific reasons behind why meditating is so helpful. Had to understand to become a believer...
Hope this helps.

REPLY
Profile picture for anniesezu812 @anniesezu812

I have been diagnosed with CRPS . My pain started with small abdominal muscle tear 2010 that was left for 6 yrs untreated. It became a very serious injury due neglect. Ultimately it went to the Celiac Plexus, im not sure in what form, irritation im guessing, seeing a Neurologist to find out but altho im not diagnosed with nerve centralization I think this is a more apt diagnosis. I result a received spinal cord stimulator last yr....with terrible results. Its just removed but due my nerves issue recovery is extremely hard and its caused numbness in my legs/ right foot.
To answer your question, if you understand Neuroplasticity ( I have read extensively on the subject being bed bound for months) theoretically you absolutely should be able to reduce/ improve your pain.
Have you heard of Joe Dispenza/Dr Sarno etc. If not Pls research. I had to read extensively to become a believer because I had had no understanding of the concept.
One has to be be very dedicated and if you choose to Meditate it is extremely hard for many to be well disciplined.
Pls Google Joe Dispenza stories of transformation for inspiration.
At this point I have nothing to loose, western medicine has pretty much destroyed my nervous system to the point of being predominantly house bound.
However post Stimulator removal 5 wjs ago im throwing myself wholeheartedly into hollistic healing. Also have you heard of TMS, similar I believe to central sensitization. ( Dont quote me on that!)
Sorry this is long.
Pls would you be kind enough to update us after your pain class. I would love to know how you make out. The Spero Clinic does wonderful work but hugely expensive. Gd Luck !!

Jump to this post

@anniesezu812 have you heard of the Spero Clinic in Fayetteville AR? They have a wonderful program for CRPS

REPLY
Profile picture for blowerk1216 @blowerk1216

@anniesezu812 have you heard of the Spero Clinic in Fayetteville AR? They have a wonderful program for CRPS

Jump to this post

@blowerk1216
I have heard of it. I did do some research and its around 30k I believe. Thank you!!
If I win the lottery I'd be happy to attend. Appreciate the info❤️

REPLY
Profile picture for anniesezu812 @anniesezu812

@blowerk1216
I have heard of it. I did do some research and its around 30k I believe. Thank you!!
If I win the lottery I'd be happy to attend. Appreciate the info❤️

Jump to this post

@anniesezu812 many people put together a go fund me to finance the program. I went to get Benign Cramp Fasciculation Syndrome addressed and indeed it was successful.

REPLY
Profile picture for blowerk1216 @blowerk1216

@anniesezu812 many people put together a go fund me to finance the program. I went to get Benign Cramp Fasciculation Syndrome addressed and indeed it was successful.

Jump to this post

@blowerk1216 I haven't heard of your syndrome. Im going to Google it. That's encouraging and I hadn't thought of a go- fund-me! Gd idea...today the pain is so excruciating I can only stand for about 1 minute...I didnt fully understand when I first read your response ....did you actually go to Spero Clinic? If so, may I ask when and how long were you there...?? Did you like the Program? Im guessing yes!! Thank you informing me of your success!
God Bless!! Im happy you are doing well.

REPLY
Profile picture for anniesezu812 @anniesezu812

@blowerk1216 I haven't heard of your syndrome. Im going to Google it. That's encouraging and I hadn't thought of a go- fund-me! Gd idea...today the pain is so excruciating I can only stand for about 1 minute...I didnt fully understand when I first read your response ....did you actually go to Spero Clinic? If so, may I ask when and how long were you there...?? Did you like the Program? Im guessing yes!! Thank you informing me of your success!
God Bless!! Im happy you are doing well.

Jump to this post

@anniesezu812 I had 14 weeks of four days a week but at the end the neuro muscular pain was alleviated

REPLY

Thank you. I will look into it.

REPLY
Please sign in or register to post a reply.