New intel re Lithium Orotate

I read with interest the comments regarding use of lithium overtake and dosages. I have been taking the orotate form now for approximately 25 years, after reading articles by Dr Jonathan V Wright, a highly known & well respected physician, who sits on the board of Life Extension after a career in alternative and allopathic medicine. He was so impressed with its qualities that he began taking it and had his whole family taking it. He recommended up to 20 mg daily. I've had little jokes and fun poked at me for years about taking Lithium, but now research is beginning to confirm Dr Wright's recommendations. Suggest researching him and the studies and recommendations on lithium orotate.

@ralpha4 worked with AI for some intel.

Yes, anti-amyloid therapies do cause corresponding changes in the Aβ42/40 ratio, often showing an increase in the ratio in CSF (cerebrospinal fluid) as plaques are cleared from the brain, reflecting the relative shift in amyloid species, while the ratio generally decreases in the blood (plasma) but serves as a key biomarker to predict amyloid status and monitor treatment effectiveness, correlating with brain amyloid PET scans.
How it Works:
Amyloid Production: The brain produces both Aβ40 and Aβ42 peptides, with Aβ42 being more prone to aggregation into plaques.
Therapy Action: Anti-amyloid drugs target and remove these plaques from the brain.
CSF Changes: As plaques (rich in Aβ42) are cleared, the balance shifts, leading to a higher Aβ42/40 ratio in the CSF, indicating successful amyloid removal.
Plasma Changes: In the blood, the Aβ42/40 ratio typically decreases, but this decrease is a strong indicator of reduced brain amyloid pathology, correlating well with amyloid PET scans.
Clinical Significance:
Screening: The plasma Aβ42/40 ratio helps identify individuals with significant brain amyloid, reducing the need for expensive PET scans.
Monitoring: Changes in the ratio (both CSF and plasma) help track treatment response, alongside other biomarkers like p-tau (phosphorylated tau).
Predicting Progression: Lower baseline Aβ42/40 ratios are linked to faster cognitive decline, highlighting its role in early disease stages.
In Summary: The Aβ42/40 ratio is a crucial blood-based biomarker that responds to anti-amyloid treatments, reflecting the removal of plaques and helping to assess disease status and treatment efficacy, despite the different directional changes seen in CSF versus plasma.

@pb50 Did you find this information on line? Did you google and find it.? Could you tell us what you asked for (typed in) when you googled if that is what you did? Would like to see the web address if that is possible.
Always good to see so much detail. Thanks for posting it.
Barbara

@blm1007blm1007
Gemini is built into Google now. There is no other web address. I believe my search query went something like
“As anti-amyloid medications reduce plasma levels of Amyloid, is that reflected in corresponding changes in plasma Aβ42/40 ratios?”

You can put instructions in with query - like please Format response like a report

I try to followup with additional queries to make sure the response is consistent. And it sometimes offers opinions unless I specify just facts and skip opinions please

Just Play with it. Fyi There are more powerful versions you can pay for

@chuckiepoo1 i am familiar with his work. And however intriguing it and other physician commentaries may be, we are just a group of like minded users of a nutritional supplement.

In my humble opinion, there may never be a pharmaceutical double blind study because there is no expensive new drug at the end of that research rainbow. Instead it is a readily available mineral that occurs in water tables in many locations and has been available as a supplement for a long time. If someone is willing to fund the research we may get guidance on dosage. But I'm not holding my breath and just thank my friends here for translating dosage from mice studies :)!

What are the possible downsides, if any ? Drug interactions, etc. am interested in hearing any info about this…want to have some more info here before i ask docs about using this.

@nycmusic when I told my SO's (82 yo female) neurologist that she and I started taking 10mg of lithium in Aug 2025 she blew me off by saying it was just a mouse study and overdose of lithium can have consequences. I reminded her that lithium carbonate is 1000 times our dosage of lithium and it's been used to treat neurological issues for years. Our dosage is only 10mg of lithium orotate. The recent "mouse" study was done by noted scientists at Harvard and is the only thing we have now. My SO was rejected as being too far along for Leqembi.

@nycmusic lithium rotate should not be taken without clearance from doctors…it does interact negatively with certain meds and NSAIDS, which can increase toxicity…many people swear by it, but be very careful with this, even though it is tempting to use it to ward off dementia.

@nycmusic the concerns you mention were taken into account when we started to take Li orotate. Thanks for mentioning other medications that can conflict!

@nycmusic you are absolutely correct that research is essential to avoid negative interactions with any drugs or supplements you may be currently taking. It isn’t a long list. But you are not likely to get “clearance” from your docs. They are professionally bound to say “wait for human trials” and there is nothing wrong with that guidance. Unfortunately some of us have a disease timeline that doesn’t accommodate a 5-8 year trial.
So follow your own instinct with my blessing. But i am confident in my preliminary research at an individual level. FYI both my Neurologist and my Primary Care and my Neuropsychologist are all in the loop.