I have both Factor V Leiden and Prothrombin mutations (Factor 2 I just read in here.)

In July 2020 I fainted at home after a night of nausea and dizziness and assumed it was a virus. The fainting alerted me to take it more seriously and in the ER discovered PE in both lungs and the saddle in between. It was life and death treatment in the ICU and I lived through it a week in the hospital. If I did not faint I likely would have died at home that day. Whew!
I have been on Elloquis 2x/day ever since. Only recently before a surgery did I consult a hematologist because the surgeon requested and it confirmed I was still on the correct dose.
You have to be careful before any surgery and always put this mutation status on health intake forms with new medical caregivers, and bring it to their attention.
I finally got a wrist band that links online to my health history in case of emergency care. I learned recently that if you are under threat of bleeding from an accident there is a drug emergency docs can administer to reverse the blood thinning temporarily- good to know as long as they know.
One brother also inherited Factor V but it seems I’m the only double blessed sibling. I’m the only female and no estrogen patches for me.
I know strokes are common in my family so I’m on a plant based whole food diet now and lowered my cholesterol risk 150 points from that alone. I take a triglyceride lowering drug also called Trilipix that brought that number way down. Good cholesterol was and is great.

I don’t smoke. I’m in my 70’s… retired and active. I do what I can and so far, so good.

Good luck!