Does MGUS ever go away?

Spontaneous Disappearance (Rare): In very rare instances, with very low levels of the abnormal protein (under 5 g/L), the protein can disappear spontaneously during monitoring, according to the NIH.

My spike has been between 3 to 5 for 10 years. Coincidentally, my pain has been chronic for over 19 years. I had never been tested for MGUS until 10 years ago for something unrelated. I now find there is a documented association between the M spike and Rheumatoid Arthritis; which I was just diagnosed with two days ago.
Terri

@rocksology hi Terri. I thought I remembered that the rheumatology research had decided that the dots between RA and MGUS were not associated. This does refute earlier findings and if you use AI, it bases its response on the outdated information.
It’s always good to talk to your hematologist/oncologist, however. None of us are physicians and there is conflicting information out there, so I’m always careful not to speak as an authority because I am not. I feel like I’m always chasing information to learn.
https://www.myeloma.org/videos/autoimmune-diseases-are-not-associated-mgus-results-population-based-istopmm

I’m absolutely not anyone who speaks with authority about anything. I’m just a research patient who doesn’t trust those with authority because I’ve been gaslit for so many years. Sadly, we can no longer trust anything anymore - especially anything in research healthcare.
I’m sorry if I came over as “authoritative”, still continuing to research. I am not a medical professional, as are most of the group members. It won’t happen again. I’ll keep to myself.
Peace and freedom from pain,
Terri.

@rocksology oh not at all. I was speaking for myself. As I read what I’d written I thought, “Gee that sounds know-it-allish” so I was trying not to sound like an authority. Not well, as I absolutely did not mean for you to feel that way.
Honestly the more I read about MGUS the less I feel that I know. There is so much to know and the information is changing so quickly. I have to remind myself that that’s a good thing because that means that the researchers are steps closer to knowing how to treat these blood disorders.
So I apologize that I did not express myself well. It sounds like you are also a MGUS information investigator, so will you let me know what else you learn?
Patty

@pmm oh geez! How i wish it would go away! But it won’t! Stay strong.. educate yourself! I am 60

I had surgery April 26,2023…i got a dvt 3 days later…i fount out in June 2023 i had mgus IgG lambda 1.6 mg/dl. In july 2023 i has an“””Ischemic stroke (by the grace of god i was on blood thinners from my DVT in late April 2023! My monoclonal cells increased from 1.6 to 1.8 to 2.0 to 2.2 g/dl. I finally had a bone marrow biopsy in May 2025 with 20-30% plasma cells with lambda restriction, flc ratio less than 0.1 g /dl and monoclonal protein 2.2 g/dl. I had two mri’s - first showing 1 focal enhancements 13 mm on first and on second mri 10/31- 3 focal enhancements 5 x 8 mm in pubic bone and 5 mm x 6 mm on R sacral ala and 4 mm x 4 mm on left sacral ala.

IgG: very high (2,803) monoclonal / involved immunoglobulin
IgA: very low (16) suppressed
IgM: low (50) suppressed

It sucks. But it never goes away. I am learning to live with the changes in my strength, endurance and health. I have sometimes done this gracefully and sometimes not. Please give yourself the space to find your strength to say that you are bigger, better and stronger than MGUS! You have a lot of support here!!

Yoga, meditation, walking, art, music are all great healing agents!