@swalex Thank you for sharing this info. I've only recently found out that my grandfather and my father have this disorder. My father was recently hospitalized with both PEs and DVTs. Although this isn't the first time, this was the first time that he was treated based on the disorder. We found out that my (deceased) grandfather had it this past Nov (25) based on testing that my aunt did. My father is 82. I have concerns for myself as a woman seeing that estrogen increases risks. Also because I have two daughters and my husband also has European ancestry (although I don't know where from. Mine is German)