Anyone experienced new or increased neuropathy with Mounjaro?

I believe I am having a neuropathic reaction. Ever since I started Mounjaro in August, I have had burning pain over most of my skin. A couple of weeks ago I missed a dose, and the pain faded away. The next week I resumed my normal injection and two days later, Bingo. Pain is back. I hadn’t made the connection until now. (I had thought it was from terbinafine…). Not sure what to do now. I was on trulicity for years and had no such issues. My PCP is kinda blowing me off, blaming diabetic neuropathy. But not with symmetrical, bilateral, widespread pain that all started at once! Frustrating.

Yes! Half my body has gone numb! I was hospitalized no answers. Forgot to take it on scheduled day numbness started receding. It didn’t click that’s what it was. I took the shot and the numbness was worse than ever stop taking it and I’m just going away but not gone. My right hand is incredibly bad and I’m an artist so this is really bad.

I found one case study reporting neuropathy from semaglutide, but that's it: https://pubmed.ncbi.nlm.nih.gov/39072425/. Doesn't mean it can't happen, but it would certainly be unexpected. My neuropathy started when I was ramping up on tirzepatide (zepbound) this summer, but I'm pretty sure that was coincidence rather than causation -- still working through the diagnostic process. Switching from tirzepatide to semaglutide next week, so it will be interesting to see if it has any impact. In my case, I suspect the neuropathy has been essentially latent for many years during which I've taken a ton of neurologically-active drugs for migraines, and emerged when I shifted to a multivitamin with a triggeringly-high dose of vitamin B6 (which happened at the same time as the tirzepatide ramp-up), and may or may not be being helped or hurt by the GLP-1RA at this point. But it's just the guess of someone who is not medically trained, so who knows?

Just an update: I've been diagnosed with drug-induced peripheral neuropathy (DIPN) in my feet from tirzepatide (zepbound). Titrating down on the dosage and then switching to semaglutide has halted the progression, but my neurologist tells me that the initial damage is likely permanent -- fortunately, it's sensory, without pain. I've been on trazodone for migraines which worked well, but ultimately produced tingling and numbness in my arms, so perhaps I had a propensity in this direction. At any rate, it's a known, extremely low probabillity (< 0.4%) side effect.

For what it's worth, I was ultimately diagnosed by neurologist who works with cancer patients. For them, DIPN is a horse -- it occurs in 60% of chemotherapy patients, so they are familiar with it and know how to identify it. For any other neurologist, it's a zebra -- it's so unlikely that they rarely consider it. I was referred to oncology when my PN labs indicated MGUS. Turned out to be a temporary indicator of a prior infection, but it got me in the door to the right person for a diagnosis.

I'm old enough and have been on enough drugs over the years that sooner or later the odds were going to catch up with me, and I would be one of those people who actually turn out to have one of those extremely rare side effects. If we took seriously the possibility that we would be that person, we would probably never take any drugs, and would just die young and in pain from something that could have been treated. So most of the time, I'm just philosophical about losing this particular lottery. Some of the time, though, I can get a bit bitchy about it.

@shaylad90 since you quit how are your symptoms?

@projfan how are you doing now? Still on GLP 1? How are your symptoms?

@projfan what was the multivitamin? How are you doing now? Are you on Tirzepatide?

@123a The multivitamin is Desert Harvest -- if you know of another one without B6, or with only a fraction of RDA, I'd be interested. And no, I switched from Tirzepatide to Ozempic to help manage the side effects. Tirzepatide makes use of a single-dose pen, while Ozempic is multi-dose, which means you can play with the dosage (although, of course, the manufacturer does not recommend this). I've been down to 0.25 mg/6 days for almost a year, although I increased to 0.5 mg for a while when I gained weight as a side effect of another medication.

@projfan endocrinologist increased my dosage from 5.0 to 7.5 resulting in AMYOTROPHY or thinning paralysis. Lost 35 lbs in 6 weeks 17lbs of lean muscle mass. Left leg paralyzed for 4 weeks. 8 months later still recovering from massive muscle loss from lower back, buttocks, hips, thighs and calves. Lots of PT and supplements to work at getting back. Now able to walk but my gait still not right. Watch out, no warning about this. The pain is terrible, be very careful!

My sister (age 74) started Monjourno in Dec 2024 and now (May 2025) been diagnosed with CIPD autoimmune disorder