@contentandwell - speaking from someone whose kidneys are failing I am not to use any medication without doctor's approval, which is obvious since most meds are filtered through the kidney and virtually everything you read says you should not take it if you have kidney issues. My nephrologist at Mayo does not want me taking Tylenol or Motrin because of the "health" of my kidneys but my daughter's kidneys function fine now and she is allowed to take Tylenol and Motrin on a limited basis when absolutely needed. I don know that Motrin, or any NSAID (non-steroidal anti-inflammatory drug), is harder for your kidneys to process.